Pharmacological studies have consistently shown memory retrieval impairment after administration of cortisol, particularly pronounced for emotional laboratory material (i.e. list of emotional words). However, it is unclear how pharmacological elevation of cortisol affects memory retrieval of ecologically-relevant emotional material (i.e. similar to a newspaper article about an emotional event). In the present study, we aimed to explore whether cortisol administration affects the recall of ecologically-relevant emotional and neutral material, and when memory retrieval occurs after a longer delay (105 min). In this double-blind, pseudo-randomized, placebo-control study, 79 participants learned a negative text and a neutral text. Twenty-four hours later, they were administrated either 10 mg of hydrocortisone or placebo. After 105 min, participants engaged in free recall of both texts. The group with cortisol administration showed significantly reduced free recall compared to the placebo group. Interestingly, this memory retrieval impairment was driven by significantly lower recall after cortisol vs. placebo administration for neutral texts, but not negative texts. The current finding suggests that cortisol administration impairs neutral ecologically-relevant material while leaving emotional material unaffected. These divergent findings, compared to existing literature, emphasize the necessity of employing more ecologically validated material to gain a more comprehensive understanding of the intricate interplay between cortisol administration and memory for ecological material.

中文翻译：

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给予皮质醇 105 分钟后，中性但非阴性物质的自由回忆受损

药理学研究一致表明，给予皮质醇后记忆检索受损，特别是对于情感实验室材料（即情感词列表）。然而，尚不清楚皮质醇的药理学升高如何影响生态相关情感材料的记忆检索（即类似于有关情感事件的报纸文章）。在本研究中，我们旨在探讨皮质醇的施用是否会影响对生态相关的情绪和中性材料的回忆，以及在较长的延迟（105 分钟）后何时发生记忆检索。在这项双盲、伪随机、安慰剂对照研究中，79 名参与者学习了负面文本和中性文本。 24 小时后，他们服用 10 毫克氢化可的松或安慰剂。 105 分钟后，参与者自由回忆这两篇文章。与安慰剂组相比，给予皮质醇的组显示出自由回忆显着减少。有趣的是，这种记忆提取障碍是由于与安慰剂相比，皮质醇给药后对中性文本（但不是负面文本）的回忆显着降低所致。目前的发现表明，皮质醇的施用会损害中性的生态相关物质，而情感物质不受影响。与现有文献相比，这些不同的发现强调了采用更多生态验证材料的必要性，以更全面地了解皮质醇管理和生态材料记忆之间复杂的相互作用。