Obesity and its associated complications pose a significant burden on health. The non-shivering thermogenesis (NST) and metabolic capacity properties of brown adipose tissue (BAT), which are distinct from those of white adipose tissue (WAT), in combating obesity and its related metabolic diseases has been well documented. However, beige adipose tissue, the third and relatively novel type of adipose tissue, which emerges in extensive presence of WAT and shares similar favorable metabolic properties with BAT, has garnered considerable attention in recent years. In this review, we focused on the role of G protein-coupled receptors (GPCRs), the largest receptor family and the most successful class of drug targets in humans, in the induction of beige adipocytes. More importantly, we highlight researchers' clinical treatment attempts to ameliorate obesity and other related metabolic diseases through the formation and activation of beige adipose tissue. In summary, this review provides valuable insights into the formation of beige adipose tissue and the involvement of GPCRs, based on the latest advancements in scientific research.

中文翻译：

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GPCR 介导的米色脂肪细胞形成调节：对肥胖和代谢健康的影响

肥胖及其相关并发症对健康造成重大负担。棕色脂肪组织（BAT）与白色脂肪组织（WAT）不同，其非颤抖产热（NST）和代谢能力特性在对抗肥胖及其相关代谢疾病方面已得到充分证明。然而，米色脂肪组织是第三种相对新颖的脂肪组织类型，它在广泛存在的 WAT 中出现，并与 BAT 具有相似的有利代谢特性，近年来引起了相当大的关注。在这篇综述中，我们重点关注了 G 蛋白偶联受体 (GPCR) 在诱导米色脂肪细胞中的作用，GPCR 是人类最大的受体家族和最成功的药物靶标。更重要的是，我们强调研究人员通过米色脂肪组织的形成和激活来改善肥胖和其他相关代谢疾病的临床治疗尝试。总之，这篇综述基于科学研究的最新进展，为米色脂肪组织的形成和 GPCR 的参与提供了有价值的见解。