Fabry disease (FD) is a rare X chromosome‐linked disorder and can be easily misdiagnosed. Here, we report the case of a 69‐year‐old male patient with FD who developed heart failure and showed extremely high pulmonary artery pressure. His initial symptom was recurrent atrial fibrillation. The left and right atrial inner diameters were large, and the ventricular wall was thick. Gene analysis which showed GLA c.215T>C p.Met72Thr mutation and single photon emission computed tomography indicated the diagnosis of FD with coronary microvascular dysfunction. The patient was prescribed anti‐heart failure drugs, including vericiguat. Following the treatment, his heart function and microvascular perfusion significantly improved, which might be due to the beneficial effects of vericiguat.

中文翻译：

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Vericiguat 改善法布里病男性患者的心功能和微循环：病例报告

法布里病 (FD) 是一种罕见的 X 染色体连锁疾病，很容易被误诊。在此，我们报告一例 69 岁男性 FD 患者，其出现心力衰竭并表现出极高的肺动脉压。他的最初症状是反复发作的心房颤动。左右心房内径较大，心室壁较厚。基因分析显示 GLA c.215T>C p.Met72Thr 突变和单光子发射计算机断层扫描提示 FD 伴有冠状动脉微血管功能障碍的诊断。患者被开了抗心力衰竭药物，包括维利西呱。治疗后，他的心脏功能和微血管灌注显着改善，这可能是由于维利呱特的有益作用。