Hepatocellular carcinoma (HCC) arises from precancerous nodules, leading to liver damage and inflammation, which triggers the release of proinflammatory cytokines. Dysregulation of these cytokines can escalate into a cytokine storm, causing severe organ damage. Interestingly, Moringa oleifera (M. oleifera) fruit peel, previously discarded as waste, contains an abundance of essential biomolecules and high nutritional value. This study focuses on the eco‐friendly synthesis of silver nanoparticles infused with M. oleifera peel extract biomolecules and their impact on regulating proinflammatory cytokines, as well as their potential anticancer effects against Wistar rats. The freshly synthesized nanoformulation underwent comprehensive characterization, followed by antihepatic cancer evaluation using a diethyl nitrosamine‐induced model (at a dose of 200 mg kg‐1 BW). The study demonstrates a significant reduction in proinflammatory cytokines such as tumor necrosis factor‐α, interleukin‐6, interleukin‐1β, and nuclear factor kappa beta (NF‐kB). Furthermore, it confirms that the newly biosynthesized silver nanoparticles exhibit additional potential against hepatic cancer due to their capped biomolecules.

中文翻译：

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辣木果皮银纳米颗粒的植物制造：通过靶向促炎细胞因子和减轻细胞因子风暴来对抗肝癌的一种有前途的方法

肝细胞癌（HCC）由癌前结节引起，导致肝脏损伤和炎症，从而引发促炎细胞因子的释放。这些细胞因子的失调可能会升级为细胞因子风暴，导致严重的器官损伤。有趣的是，以前被当作废物丢弃的辣木果皮含有丰富的必需生物分子和很高的营养价值。本研究重点关注注入油茶果皮提取物生物分子的银纳米颗粒的环保合成及其对调节促炎细胞因子的影响，以及它们对 Wistar 大鼠的潜在抗癌作用。新合成的纳米制剂经过全面表征，然后使用二乙基亚硝胺诱导模型（剂量为 200 mg kg-1 BW）进行抗肝癌评估。该研究表明促炎细胞因子显着减少，例如肿瘤坏死因子-α、白细胞介素-6、白细胞介素-1β 和核因子 kappa β (NF-kB)。此外，它证实新生物合成的银纳米颗粒由于其封端生物分子而表现出抗肝癌的额外潜力。