Goniomitine is of the aspidosperma alkaloid family, with an angularly fused tetracyclic skeleton housing an all‐carbon quaternary carbon chiral center alongside an aminal functional group. This natural product has garnered attention as a synthetic target due to its intriguing molecular architecture and anti‐proliferative activity in recent years. Following the first synthesis of (‐)‐goniomitine by Takano in 1991, synthetic chemists have developed various methods. This review provides an overview of the methodologies used in the synthesis of goniomitine in racemic and enantiopure forms via divergent construction indole framework, indole functionalization, and the integrated oxidation/reduction/cyclization (iORC) sequence from 1991 to 2023.

中文翻译：

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蜘蛛吲哚生物碱Goniomitine的合成研究进展及策略

Goniomitine 属于蜘蛛植物生物碱家族，具有有角度稠合的四环骨架，其中包含全碳季碳手性中心以及缩醛胺官能团。近年来，这种天然产物因其有趣的分子结构和抗增殖活性而作为合成靶点而受到关注。继 Takano 于 1991 年首次合成 (‐)-goniomitine 后，合成化学家开发了各种方法。本综述概述了 1991 年至 2023 年通过不同结构吲哚框架、吲哚官能化和集成氧化/还原/环化 (iORC) 序列合成外消旋和对映体纯形式 goniomitine 的方法。