Objective

The aim of the study is to analyze microstate patterns in GLUT1-DS, both before and after the ketogenic diet (KD).

Methods

We conducted microstate analysis of a patient with GLUT-1 DS and 27 healthy controls. A systematic literature review and meta-analysis was done. We compared the parameters of the patients with those of healthy controls and the incorporating findings in literature.

Results

The durations of the patient were notably shorter, and the occurrence rates were longer than those of healthy controls and incorporating findings from the review. After 10 months of KD, the patient’s microstate durations exhibited an increase from 53.05 ms, 57.17 ms, 61.80 ms, and 49.49 ms to 60.53 ms, 63.27 ms, 71.11 ms, and 66.55 ms. The occurrence rates changed from 4.0774 Hz, 4.9462 Hz, 4.8006 Hz, and 4.0579 Hz to 3.3354 Hz, 3.7893 Hz, 3.5956 Hz, and 4.1672 Hz. In healthy controls, the durations of microstate class A, B, C, and D were 61.86 ms, 63.58 ms, 70.57 ms, and 72.00 ms, respectively.

Conclusions

Our findings suggest EEG microstates may be a promising biomarker for monitoring the effect of KD. Administration of KD may normalize the dysfunctional patterns of temporal parameters.

中文翻译：

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利用脑电图微状态作为前瞻性生物标志物评估生酮饮食对 GLUT1-DS 的影响

客观的

该研究的目的是分析生酮饮食 (KD) 之前和之后 GLUT1-DS 的微观状态模式。

方法

我们对一名 GLUT-1 DS 患者和 27 名健康对照者进行了微观状态分析。进行了系统的文献综述和荟萃分析。我们将患者的参数与健康对照的参数以及文献中的研究结果进行了比较。

结果

与健康对照组相比，患者的持续时间明显更短，并且发生率更长，并结合了审查结果。 KD 10 个月后，患者的微状态持续时间从 53.05 ms、57.17 ms、61.80 ms 和 49.49 ms 增加到 60.53 ms、63.27 ms、71.11 ms 和 66.55 ms。发生率从4​​.0774 Hz、4.9462 Hz、4.8006 Hz和4.0579 Hz变为3.3354 Hz、3.7893 Hz、3.5956 Hz和4.1672 Hz。在健康对照中，A、B、C 和 D 级微状态的持续时间分别为 61.86 ms、63.58 ms、70.57 ms 和 72.00 ms。

结论

我们的研究结果表明，脑电图微状态可能是监测 KD 效果的有前途的生物标志物。 KD 的施用可以使时间参数的功能失调模式正常化。