Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with systemic symptoms. Periodontitis, a prevalent dental disease, shares immune-mediated inflammatory characteristics with HS. This cohort study aims to evaluate the association between HS and periodontitis./nMethods: Using the TriNetX research network, a global-federated database of electronic health records, we conducted a retrospective cohort study. People being diagnosed of HS were identified and propensity score matching was performed to identify proper control group, via balancing critical covariates Within the follow-up time of 1 year, 3 year and 5 years, hazard ratios were calculated to assess the risk of periodontitis in HS patients compared to controls./nResults: Within the 53,968 HS patients and the same number of matched controls, the HS patients exhibited a significantly increased risk of developing periodontitis compared to controls after 3 years of follow-up (HR: 1.64, 95% CI: 1.11, 2.44) and 5 years of follow-up (HR: 1.64, 95% CI: 1.21, 2.24) of follow-up. Sensitivity analyses supported these findings under various matching models and washout periods. While comparing with patients with psoriasis, the association between HS and periodontitis remained significant (HR: 1.73, 95% CI: 1.23, 2.44)./nConclusion: The observed increased risk suggests the need for heightened awareness and potential interdisciplinary care for individuals with HS to address periodontal health.

中文翻译：

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化脓性汗腺炎作为牙周炎的潜在危险因素：一项多中心、倾向评分匹配队列研究

背景：化脓性汗腺炎（HS）是一种与全身症状相关的慢性炎症性皮肤病。牙周炎是一种常见的牙科疾病，与 HS 具有免疫介导的炎症特征。本队列研究旨在评估 HS 与牙周炎之间的关联。/n方法：利用 TriNetX 研究网络（全球电子健康记录联合数据库），我们进行了一项回顾性队列研究。确定被诊断为 HS 的人，并进行倾向评分匹配，通过平衡关键协变量来确定适当的对照组。在 1 年、3 年和 5 年的随访时间内，计算风险比来评估牙周炎的风险。 HS 患者与对照组相比。/n结果：在 53,968 名 HS 患者和相同数量的匹配对照中，3 年随访后，与对照组相比，HS 患者发生牙周炎的风险显着增加（HR：1.64、95） % CI：1.11，2.44）和 5 年随访（HR：1.64，95% CI：1.21，2.24）。敏感性分析在各种匹配模型和清洗期下支持了这些发现。与银屑病患者相比，HS 与牙周炎之间的关联仍然显着（HR：1.73，95% CI：1.23，2.44）。/n结论：观察到的风险增加表明需要提高对患有 HS 的患者的认识和潜在的跨学科护理HS 解决牙周健康问题。