The development of antioxidant wound dressings to remove excessive free radicals around wounds is essential for wound healing. In this study, we developed an efficient strategy to prepare antioxidant self-healing hydrogels as wound dressings by combining multicomponent reactions (MCRs) and postpolymerization modification. A polymer containing ferrocene and phenylboronic acid groups was developed via the Biginelli reaction, followed by efficient modification. This polymer is antioxidant due to its ferrocene moieties and can rapidly cross-link poly(vinyl alcohol) to realize an antioxidant self-healing hydrogel through dynamic borate ester linkages. This hydrogel has low cytotoxicity and is biocompatible. In in vivo experiments, this hydrogel is superior to existing clinical dressings in promoting wound healing. This study demonstrates the value of the Biginelli reaction in exploring biomaterials, potentially offering insights into the design of other multifunctional polymers and related materials using different MCRs.

中文翻译：

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基于二茂铁的抗氧化剂自愈水凝胶通过 Biginelli 反应促进伤口愈合

开发抗氧化伤口敷料以清除伤口周围过多的自由基对于伤口愈合至关重要。在这项研究中，我们开发了一种有效的策略，通过结合多组分反应（MCR）和后聚合改性来制备抗氧化自修复水凝胶作为伤口敷料。通过 Biginelli 反应开发出含有二茂铁和苯基硼酸基团的聚合物，然后进行有效改性。该聚合物因其二茂铁部分而具有抗氧化性，并且可以快速交联聚乙烯醇，通过动态硼酸酯键实现抗氧化自修复水凝胶。这种水凝胶具有低细胞毒性且具有生物相容性。在体内实验中，这种水凝胶在促进伤口愈合方面优于现有的临床敷料。这项研究证明了 Biginelli 反应在探索生物材料方面的价值，可能为使用不同 MCR 设计其他多功能聚合物和相关材料提供见解。