SummarySensory signals detected by olfactory sensory organs are critical regulators of animal behavior. An accessory olfactory organ, the vomeronasal organ, detects cues from other animals and plays a pivotal role in intra‐ and inter‐species interactions in mice. However, how ethologically relevant cues control mouse behavior through approximately 350 vomeronasal sensory receptor proteins largely remains elusive. The type 2 vomeronasal receptor‐A4 (V2R‐A4) subfamily members have been repeatedly detected from vomeronasal sensory neurons responsive to predator cues, suggesting a potential role of this receptor subfamily as a sensor for predators. This review focuses on this intriguing subfamily, delving into its receptor functions and genetic characteristics.

中文翻译：

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2 型犁鼻受体-A4 亚家族：小鼠中潜在的捕食者传感器

摘要嗅觉感觉器官检测到的感觉信号是动物行为的关键调节器。犁鼻器是一种辅助嗅觉器官，可以检测来自其他动物的信号，并在小鼠的物种内和物种间相互作用中发挥关键作用。然而，行为学相关线索如何通过大约 350 种犁鼻感觉受体蛋白控制小鼠行为在很大程度上仍然难以捉摸。 2 型犁鼻受体-A4 (V2R-A4) 亚家族成员已在对捕食者线索作出反应的犁鼻感觉神经元中反复检测到，表明该受体亚家族作为捕食者传感器的潜在作用。本综述重点关注这个有趣的亚家族，深入研究其受体功能和遗传特征。