BACKGROUNDPeptides have been studied in Caenorhabditis elegans for anti‐aging research recently. Due to the lack of sufficient evidence, we conducted this meta‐analysis focusing on the anti‐aging effect of peptides in C. elegans to provide more convincing evidence.RESULTSA literature search in PubMed, SCOUPUS, and Web of Science databases yielded 2879 articles. After removing duplicates and based on inclusion criteria and STAIR checklist quality assessment, 9 articles were selected. Data extraction and analysis showed that, compared to the control group without peptide intervention, peptide supplementation significantly reduced nematode mortality risk (HR= 0.54, 95% CI = 0.47, 0.62; p < 0.05), significantly increased the pharyngeal pumping rate (SMD = 1.64, 95% CI = 0.87, 2.41; p < 0.05), bending frequency (SMD = 1.67, 95% CI =1.16, 2.18; p < 0.05), and significantly decreased the accumulation of lipofuscin levels within nematodes (SMD = ‐4.48, 95% CI = ‐6.85, ‐2.12; p < 0.05). Additionally, subgroup analysis showed that doses ranging from 0.1–1 kg m3 ^‐1 (HR= 0.50, 95% CI = 0.38, 0.65; p < 0.05) displayed better anti‐aging effects compared to other dose ranges.CONCLUSIONThe findings suggest that peptides can significantly extend the lifespan of C. elegans under normal circumstances and improve three indicators of healthylife. More importantly, subgroup analysis revealed that a dosage of 0.1–1 kg m3 ^‐1 demonstrated superior anti‐aging effects. This meta‐analysis provides more convincing evidence that peptides can play an anti‐aging role in C. elegans.This article is protected by copyright. All rights reserved.

中文翻译：

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肽对秀丽隐杆线虫的抗衰老作用：荟萃分析

背景最近，人们对秀丽隐杆线虫中的肽进行了抗衰老研究。由于缺乏足够的证据，我们针对秀丽隐杆线虫肽的抗衰老作用进行了荟萃分析，以提供更有说服力的证据。 结果在 PubMed、SCOUPUS 和 Web of Science 数据库中进行文献检索，共获得 2879 篇文章。去除重复项后，根据纳入标准和 STAIR 检查表质量评估，选出 9 篇文章。数据提取和分析表明，与没有肽干预的对照组相比，补充肽显着降低了线虫死亡风险（HR = 0.54，95％CI = 0.47，0.62；p < 0.05），显着增加了咽泵血率（SMD = 1.64，95% CI = 0.87，2.41；p < 0.05），弯曲频率（SMD = 1.67，95% CI =1.16，2.18；p < 0.05），并显着降低线虫内脂褐素水平的积累（SMD = ‐4.48） ，95% CI = ‐6.85，‐2.12；p < 0.05）。此外，亚组分析表明，剂量范围为 0.1–1 kg m3^‐1 (HR= 0.50, 95% CI = 0.38, 0.65; p < 0.05) 与其他剂量范围相比表现出更好的抗衰老效果。 结论 研究结果表明，肽在正常情况下可以显着延长秀丽隐杆线虫的寿命，并且提高健康生活三项指标。更重要的是，亚组分析表明，0.1-1 kg m3^‐1表现出卓越的抗衰老作用。这项荟萃分析提供了更有说服力的证据，证明肽可以在线虫中发挥抗衰老作用。本文受版权保护。版权所有。