Abstract

Secondary metabolites produced by actinomycete strains undoubtedly have great potential for use in applied research areas such as drug discovery. However, it is becoming difficult to obtain novel compounds because of repeated isolation around the world. Therefore, a new strategy for discovering novel secondary metabolites is needed. Many researchers believe that actinomycetes have as yet unanalyzed secondary metabolic activities, and the associated undiscovered secondary metabolite biosynthesis genes are called “silent” genes. This review outlines several approaches to further activate the metabolic potential of actinomycetes.

Beilstein J. Org. Chem. 2024, 20, 753–766. doi:10.3762/bjoc.20.69

摘要

放线菌菌株产生的次生代谢产物无疑在药物发现等应用研究领域具有巨大的应用潜力。然而，由于世界各地的反复分离，获得新化合物变得越来越困难。因此，需要一种发现新型次生代谢物的新策略。许多研究人员认为，放线菌具有尚未分析的次生代谢活性，相关的未发现的次生代谢物生物合成基因被称为“沉默”基因。这篇综述概述了进一步激活放线菌代谢潜力的几种方法。

贝尔斯坦 J. 组织。化学。 2024, 20, 753–766。 doi:10.3762/bjoc.20.69