Childhood cancer survivorship studies generate comprehensive datasets comprising demographic, diagnosis, treatment, outcome, and genomic data from survivors. To broadly share this data, we created the St. Jude Survivorship Portal (https://survivorship.stjude.cloud), the first data portal for sharing, analyzing, and visualizing pediatric cancer survivorship data. Over 1,600 phenotypic variables and 400 million genetic variants from over 7,700 childhood cancer survivors can be explored on this free, open-access portal. Summary statistics of variables are computed on-the-fly and visualized through interactive and customizable charts. Survivor cohorts can be customized and/or divided into groups for comparative analysis. Users can also seamlessly perform cumulative incidence and regression analyses on the stored survivorship data. Using the portal, we explored the ototoxic effects of platinum-based chemotherapy, uncovered a novel association between mental health, age, and limb amputation, and discovered a novel haplotype in MAGI3 strongly associated with cardiomyopathy specifically in survivors of African ancestry.

中文翻译：

---

St. Jude Survivorship Portal：共享和分析儿科癌症幸存者的大型临床和基因组数据集

儿童癌症生存研究生成全面的数据集，包括幸存者的人口统计、诊断、治疗、结果和基因组数据。为了广泛共享这些数据，我们创建了 St. Jude Survivorship Portal (https://survivorship.stjude.cloud)，这是第一个用于共享、分析和可视化儿科癌症生存数据的数据门户。可以在这个免费、开放访问的门户上探索来自 7,700 多名儿童癌症幸存者的 1,600 多个表型变量和 4 亿个遗传变异。变量的汇总统计数据是即时计算的，并通过交互式和可定制的图表进行可视化。幸存者队列可以定制和/或分组进行比较分析。用户还可以对存储的生存数据无缝执行累积发生率和回归分析。使用该门户网站，我们探索了铂类化疗的耳毒性作用，发现了心理健康、年龄和截肢之间的新关联，并发现了 MAGI3 中的一种新单倍型，该单倍型与心肌病密切相关，特别是在非洲血统的幸存者中。