: Neurodegenerative diseases are emerging as a global health concern in the current sce-nario, and their association with mitochondrial defects has been a potential area of research. Mi-tochondria, one of the essential organelles of the cell, serve as the cell's powerhouse, producing energy and ensuring cellular health. Neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and Pelizaeus-Merzbacher disease have been found to be primarily triggered by mitochondrial malfunction. One of the key byproducts of mitochondrial respiration, reactive oxygen species, also contributes significantly to mitochondrial DNA muta-tions that eventually cause mitochondrial breakdown. This review paper comprehensively examines the potential of therapeutic biomolecules, specifi-cally mitochondria-specific antioxidants, in mitigating the impact of mitochondrial defects on neurodegenerative diseases. It provides a detailed analysis of the mechanisms involved in mito-chondrial dysfunction, the potential therapeutic targets of these biomolecules, and their structure-activity relationship information are also discussed in this review. Various research articles and publications were used extensively in compiling the data, and the structures of biomolecules were prepared using software such as ChemDraw and ChemSketch. Crucial elements triggering mitochondrial abnormalities were identified and a tabular compilation of bioactive antioxidant compounds along with their therapeutic targets, was presented. Mitochondria-specific antioxidant therapy is an innovative and promising strategy for the man-agement of neurodegenerative diseases associated with mitochondrial defects. This review pro-vides a thorough summary of the current state of research and promising avenues of research and development in this field, emphasizing the importance of further investigations and clinical trials to elucidate their therapeutic benefits.

中文翻译：

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通过治疗性生物分子减轻与线粒体缺陷相关的神经退行性疾病

：在当前情况下，神经退行性疾病正在成为全球健康问题，其与线粒体缺陷的关联已成为潜在的研究领域。线粒体是细胞的重要细胞器之一，是细胞的动力源，产生能量并确保细胞健康。人们发现，阿尔茨海默病、帕金森病、亨廷顿舞蹈症、肌萎缩侧索硬化症和佩利扎乌斯-梅茨巴赫病等神经退行性疾病主要是由线粒体功能障碍引发的。线粒体呼吸的主要副产品之一活性氧也会导致线粒体 DNA 突变，最终导致线粒体分解。这篇综述论文全面研究了治疗性生物分子，特别是线粒体特异性抗氧化剂在减轻线粒体缺陷对神经退行性疾病影响方面的潜力。它详细分析了线粒体功能障碍的机制、这些生物分子的潜在治疗靶点以及它们的结构-活性关系信息，本综述也进行了讨论。各种研究文章和出版物被广泛用于编译数据，并使用 ChemDraw 和 ChemSketch 等软件准备生物分子的结构。确定了引发线粒体异常的关键因素，并提出了生物活性抗氧化化合物及其治疗靶点的表格汇编。线粒体特异性抗氧化疗法是治疗与线粒体缺陷相关的神经退行性疾病的一种创新且有前景的策略。这篇综述对该领域的研究现状和有前途的研究和开发途径进行了全面总结，强调了进一步研究和临床试验以阐明其治疗益处的重要性。