Background: Periodontitis and benign prostatic hyperplasia (BPH) are all common chronic diseases with higher incidence in middle-aged and old men. Several studies have indicated a potential association between periodontitis and BPH, although the findings remain inconclusive. However, there is no mendelian randomization (MR) studies to assess this association.Methods: The 40 men who had received health check-ups were included in an epidemiological study. Genetic data of BPH (13118 cases and 72799 controls) and periodontitis (3046 cases and 195395 controls) from FinnGen project was used to perform two-sample MR analysis. The inverse-variance weighted (IVW) model was identified as the primary analytical method, with MR Egger, weighted median, simple mode, and weighted mode serving as additional approaches.Results: The epidemiological analysis demonstrated a lack of statistically significant differences in the prevalence of clinical BPH between severe periodontitis group and non-severe periodontitis group. Similarly, no statistically significant differences were found in the prevalence of severe periodontitis among individuals with clinical BPH compared to those without. Additionally, Among the five models utilized in MR analysis, including the IVW model, no evidence of a causal link between periodontitis and BPH was observed.Conclusion: The findings from our epidemiological investigation and MR analysis do not provide support for a causal relationship between periodontitis and BPH.

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牙周炎与良性前列腺增生之间双向因果关系的评估：流行病学研究和双样本孟德尔随机分析

背景：牙周炎和良性前列腺增生（BPH）都是常见的慢性疾病，在中老年男性中发病率较高。多项研究表明牙周炎与良性前列腺增生之间存在潜在关联，但研究结果仍无定论。然而，没有孟德尔随机化 (MR) 研究来评估这种关联。方法：流行病学研究纳入了 40 名接受过健康检查的男性。 FinnGen 项目中的 BPH（13118 例病例和 72799 例对照）和牙周炎（3046 例病例和 195395 例对照）的遗传数据用于进行两样本 MR 分析。逆方差加权（IVW）模型被确定为主要分析方法，MR Egger、加权中位数、简单模式和加权模式作为附加方法。结果：流行病学分析表明，患病率缺乏统计学上的显着差异。重症牙周炎组与非重症牙周炎组临床BPH的比较同样，与没有临床 BPH 的个体相比，在患有临床 BPH 的个体中，严重牙周炎的患病率没有发现统计学上的显着差异。此外，在MR分析中使用的五个模型中，包括IVW模型，没有观察到牙周炎与BPH之间存在因果关系的证据。结论：我们的流行病学调查和MR分析的结果并不能支持牙周炎之间的因果关系。和前列腺增生。