This study examined brain functional connectivity (FC) changes associated with possible anomalous interactions between sensorily isolated monozygotic (MZ) twins. Brain FC was estimated using the Steady State Visual Evoked Potential-Event Related Partial Coherence (SSVEP-ERPC) methodology. Five twin pairs served twice as participants, with an average interval between sessions of 67 days. In each recording session, one twin, the Sender, viewed a randomized set of 50 general images and 50 personally relevant images, while the other twin, the Receiver, viewed a static personally relevant image for the entire duration of the session. Images appeared on the Sender screen for 1.0 s, with the interval between successive images varied randomly between 4.0 and 8.0 s. Receiver FC changes were calculated based on the appearance times of the images as viewed by the Sender. It was hypothesized that anomalous interactions would be indicated by statistically significant Receiver FC changes when those changes are determined using the Sender image appearance times. For each twin serving as Receiver, FC components were separately analyzed for the 50 general and the 50 personal images, yielding 38 observations (19 twin pairs by 2 conditions). The hypothesis was confirmed in that 11 of the 38 observations yielded statistically significant Receiver FC increases or decreases at the p < 0.01 level only when trials were synchronized to the Sender image appearance times. Overall, this effect was significant at the p = 4 × 10−8 Df = 175. To the best of our knowledge, this is the first study reporting statistically significant FC changes indicative of anomalous interactions between two sensorily isolated individuals.

中文翻译：

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大脑功能连接与感觉孤立的同卵双胞胎之间的异常相互作用相关

这项研究检查了与感觉孤立的同卵（MZ）双胞胎之间可能的异常相互作用相关的大脑功能连接（FC）变化。使用稳态视觉诱发电位事件相关部分相干性 (SSVEP-ERPC) 方法估计大脑 FC。五对双胞胎担任两次参与者，平均会议间隔为 67 天。在每个记录会话中，一个双胞胎（发送者）观看一组随机的 50 张一般图像和 50 个个人相关图像，而另一个双胞胎（接收者）在整个会话期间查看静态的个人相关图像。图像在发送者屏幕上显示 1.0 秒，连续图像之间的间隔在 4.0 到 8.0 秒之间随机变化。接收方 FC 变化是根据发送方查看的图像出现时间计算的。据推测，当使用发送方图像出现时间确定这些变化时，异常交互将通过统计上显着的接收方 FC 变化来指示。对于作为接收者的每对双胞胎，分别分析 50 个一般图像和 50 个个人图像的 FC 组件，产生 38 个观察结果（2 个条件下的 19 对双胞胎）。该假设得到证实，38 个观测值中有 11 个在接收器 FC 值处产生了统计显着的增加或减少。p<仅当试验与发件人图像出现时间同步时才为 0.01 级别。总体而言，这一影响在p= 4 × 10−8Df = 175。据我们所知，这是第一项报告统计上显着的 FC 变化的研究，表明两个感觉孤立的个体之间存在异常相互作用。