Gastrointestinal impairment induced sleep, behavioral and psychiatric disorders were reported in patients of autism spectrum disorders (ASDs). These may be life-long neuro-developmental disorders. Standardized diagnostic criteria for ASDs include: restricted and repetitive behavior, ongoing deficiencies in social interaction and communication. Pro-antioxidant and anti-inflammatory effects of dietry polyphenols/poly-phenol-rich derivatives as bioactive compounds enhanced permeability of blood brain barrier, consequently leads to delay in the onset of ASDs symptoms and can be effectively used in the management of ASDs. During the research on ASDs numerous therapeutic modalities, such as chemical and plant-based therapies, have been investigated. Due to their possible neuro-psychopharmacological benefits, plant-based treatments have attracted interest. These natural source therapies have demonstrated potential in reducing ASDs-related symptoms. Plant-based psycho-pharmaceuticals have been thoroughly investigated, and the investigations have confirmed their therapeutic effects. The therapeutic qualities of plants not only address the complex neurological aspects of ASDs but also provide a comprehensive approach to treatment. These substances may restore neurochemical equilibrium by focusing on particular biochemical pathways associated with the illness. Advancements in pharmacology and neurochemistry have enabled targeted interventions through chemical approaches. The treatment of ASDs approached through a combination of plant-based solutions and chemical methods can be better than one alone. By targeting the restorative properties of both natural compounds and synthesized chemicals, researchers aim to address the diverse range of symptoms and underlying neurobiological abnormalities associated with ASDs. Further clinical studies are required to validate the potential of bioactive molecules scientifically.

Graphical Abstract

中文翻译：

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自闭症谱系障碍 (ASD) 精神药物治疗的植物药物和化学方法综合综述

据报道，自闭症谱系障碍 (ASD) 患者因胃肠道损伤而导致睡眠、行为和精神障碍。这些可能是终生的神经发育障碍。自闭症谱系障碍的标准化诊断标准包括：受限和重复的行为、持续的社交互动和沟通缺陷。膳食多酚/富含多酚的衍生物作为生物活性化合物，具有抗氧化和抗炎作用，可增强血脑屏障的通透性，从而延迟自闭症谱系障碍症状的出现，可有效用于自闭症谱系障碍的治疗。在自闭症谱系障碍的研究过程中，人们对多种治疗方式进行了研究，例如化学疗法和植物疗法。由于植物性治疗可能具有神经心理药理学益处，因此引起了人们的兴趣。这些天然来源疗法已被证明可以减少 ASD 相关症状。植物性精神药物已被彻底研究，研究证实了其治疗效果。植物的治疗特性不仅可以解决自闭症谱系障碍的复杂神经学问题，还可以提供全面的治疗方法。这些物质可以通过关注与疾病相关的特定生化途径来恢复神经化学平衡。药理学和神经化学的进步使得通过化学方法进行有针对性的干预成为可能。通过植物性解决方案和化学方法相结合来治疗自闭症谱系障碍可能比单独使用一种方法更好。通过针对天然化合物和合成化学物质的恢复特性，研究人员旨在解决与自闭症谱系障碍相关的各种症状和潜在的神经生物学异常。需要进一步的临床研究来科学地验证生物活性分子的潜力。

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