The skin is the largest organ of the body, and it acts as a protective barrier against external factors. Chronic wounds affect millions of people worldwide and are associated with significant morbidity and reduced quality of life. One of the main factors involved in delayed wound healing is oxidative injury, which is triggered by the overproduction of reactive oxygen species. Oxidative stress has been implicated in the pathogenesis of chronic wounds, where it is known to impair wound healing by causing damage to cellular components, delaying the inflammatory phase of healing, and inhibiting the formation of new blood vessels. Thereby, the treatment of chronic wounds requires a multidisciplinary approach that addresses the underlying causes of the wound, provides optimal wound care, and promotes wound healing. Among the promising approaches to taking care of chronic wounds, antioxidants are gaining interest since they offer multiple benefits related to skin health. Therefore, in this review, we will highlight the latest advances in the use of natural polymers with antioxidants to generate tissue regeneration microenvironments for skin wound healing.

中文翻译：

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使用水凝胶在皮肤伤口中提供抗氧化剂的进展

皮肤是身体最大的器官，它充当抵御外部因素的保护屏障。慢性伤口影响着全世界数百万人，并与显着的发病率和生活质量下降有关。伤口愈合延迟的主要因素之一是氧化损伤，这是由活性氧过度产生引起的。氧化应激与慢性伤口的发病机制有关，已知它会通过对细胞成分造成损害、延迟愈合的炎症阶段并抑制新血管的形成来损害伤口愈合。因此，慢性伤口的治疗需要采用多学科方法来解决伤口的根本原因，提供最佳的伤口护理并促进伤口愈合。在治疗慢性伤口的有前途的方法中，抗氧化剂越来越受到人们的关注，因为它们提供与皮肤健康相关的多种益处。因此，在这篇综述中，我们将重点介绍使用天然聚合物与抗氧化剂来生成组织再生微环境以促进皮肤伤口愈合的最新进展。