Major depressive disorder (MDD) tends to emerge during adolescence, but the neurobiology of adolescent MDD is still poorly understood. This study aimed to explore the topological organization of white matter structural networks and the relationship between structural and functional connectivity in adolescent MDD. Structural and functional magnetic resonance imaging data were acquired from 94 first-episode drug-naïve adolescent MDD patients and 78 healthy adolescents. Whole brain structural and functional brain networks were constructed for each subject. Then, the topological organization of structural brain networks and the coupling strength between structural and functional connectivity were analyzed. Compared with controls, adolescent MDD patients showed disrupted small-world, rich-club, and modular organizations. Nodal centralities in the medial part of bilateral superior frontal gyrus, bilateral hippocampus, right superior occipital gyrus, right angular gyrus, bilateral precuneus, left caudate nucleus, bilateral putamen, right superior temporal gyrus, and right temporal pole part of superior temporal gyrus were significantly lower in adolescent MDD patients compared with controls. The coupling strength between structural and functional connectivity was significantly lower in adolescent MDD patients compared with controls. Our findings suggest widespread disruption of structural brain networks and structural-functional decoupling in adolescent MDD, potentially leading to reduced network communication capacity.

中文翻译：

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首发未用药青少年重度抑郁症中大脑结构网络的破坏和结构功能解耦

重度抑郁症（MDD）往往在青春期出现，但青少年 MDD 的神经生物学仍然知之甚少。本研究旨在探讨青少年MDD白质结构网络的拓扑组织以及结构和功能连接之间的关系。结构和功能磁共振成像数据来自 94 名首次用药青少年 MDD 患者和 78 名健康青少年。为每个受试者构建了全脑结构和功能脑网络。然后，分析了结构性脑网络的拓扑组织以及结构性和功能性连接之间的耦合强度。与对照组相比，青少年 MDD 患者表现出小世界、富俱乐部和模块化组织的混乱。双侧额上回内侧部分、双侧海马、右枕上回、右角回、双侧楔前叶、左尾状核、双侧壳核、右颞上回、右颞上回颞极部分显着与对照组相比，青少年 MDD 患者的水平较低。与对照组相比，青少年 MDD 患者的结构和功能连接之间的耦合强度显着较低。我们的研究结果表明，青少年抑郁症患者的大脑结构网络普遍受到破坏，结构与功能脱钩，可能导致网络通信能力下降。