In this study, silver nanoparticles (AgNPs) were synthesized using pulsed laser deposition and deposited on a sheet film composed of Carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA), and AgNPs. These polymeric-based nano-composites were investigated for their potential application in wound healing. The structural properties of the composites were examined using X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). Morphological features were observed through field emission scanning electron microscopy (FESEM), and roughness characteristics were studied using FESEM micrographs. The CMC-PVA-AgNPs scaffolds with deposition times of 10 and 12.5 min showed minimal deviations in surface structure compared to the composites with longer deposition times, where scattered AgNPs and aggregates were observed. Furthermore, the roughness parameter (Ra) values indicated the potential of silver NPs in creating trapping sites and crystal defects, as evidenced by an increase in Ra from 18.96 nm in the pure CMC-PVA blend to 34.17 nm at a deposition time of 20 min. The optical properties of the composites were investigated by determining the band-gap of direct and indirect transition modes, which exhibited a decreasing trend. The presence of silver NPs was confirmed by the plasmon absorption band observed around 400 nm. The intensity of the plasmon peaks increased with longer laser deposition times, indicating an increase in the silver content over time. Finally, the antibacterial activity of the prepared scaffolds against , , , and was evaluated, and the results strongly support the potential of the prepared material for biological applications. In conclusion, the synthesized CMC-PVA-AgNPs nano-composites deposited using pulsed laser deposition technique exhibited promising properties for wound healing applications. The comprehensive characterization of the composites, including their structural, morphological, optical, and antibacterial properties, provides valuable insights for further research and development in the field of biomaterials.

中文翻译：

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激光沉积超薄银纳米粒子在 CMC-PVA 共混薄膜上作为伤口敷料片材

在这项研究中，采用脉冲激光沉积法合成银纳米颗粒（AgNP），并将其沉积在由羧甲基纤维素（CMC）、聚乙烯醇（PVA）和AgNP组成的片状薄膜上。研究了这些基于聚合物的纳米复合材料在伤口愈合中的潜在应用。使用 X 射线衍射 (XRD) 和傅里叶变换红外光谱 (FTIR) 检查复合材料的结构性能。通过场发射扫描电子显微镜 (FESEM) 观察形态特征，并使用 FESEM 显微照片研究粗糙度特征。与沉积时间较长的复合材料相比，沉积时间为 10 和 12.5 分钟的 CMC-PVA-AgNPs 支架在表面结构上显示出最小的偏差，其中观察到分散的 AgNPs 和聚集体。此外，粗糙度参数 (Ra) 值表明银纳米粒子在产生捕获位点和晶体缺陷方面的潜力，沉积时间为 20 分钟时，Ra 从纯 CMC-PVA 混合物中的 18.96 nm 增加到 34.17 nm。 。通过确定直接和间接跃迁模式的带隙来研究复合材料的光学性质，其呈现出减小的趋势。通过在 400 nm 附近观察到的等离子体吸收带证实了银纳米颗粒的存在。等离激元峰的强度随着激光沉积时间的延长而增加，表明银含量随着时间的推移而增加。最后，对所制备的支架的抗菌活性进行了评估，结果有力地支持了所制备材料的生物应用潜力。总之，使用脉冲激光沉积技术沉积的合成的 CMC-PVA-AgNPs 纳米复合材料在伤口愈合应用中表现出有前景的特性。复合材料的全面表征，包括其结构、形态、光学和抗菌性能，为生物材料领域的进一步研究和开发提供了宝贵的见解。