The concept of the Land of Not-Unhappiness refers to the potential achievement of eliminating the pathologies of the aging process. To inform of how close we are to settling in the land, we summarize and review the achievements of research on anti-aging interventions over the last hundred years with a specific focus on strategies that slow down metabolism, compensate for aging-related losses, and target a broad range of age-related diseases. We critically evaluate the existing interventions labeled as "anti-aging," such as calorie restriction, exercise, stem cell administration, and senolytics, to provide a down-to-earth evaluation of their current applicability in counteracting aging. Throughout the text, we have maintained a light tone to make it accessible to non-experts in biogerontology, and provide a broad overview for those considering conducting studies, research, or seeking to understand the scientific basis of anti-aging medicine.

中文翻译：

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在不幸福的土地上：论通过生物医学研究对抗衰老和与年龄相关的疾病的最新技术

无苦之地的概念是指消除衰老过程中的病理现象的潜在成就。为了了解我们离定居这片土地还有多远，我们总结和回顾了过去百年来抗衰老干预措施的研究成果，特别关注减缓新陈代谢、补偿衰老相关损失和预防衰老的策略。针对广泛的与年龄相关的疾病。我们批判性地评估现有的标有“抗衰老”的干预措施，例如热量限制、锻炼、干细胞施用和抗衰老药物，以对其当前对抗衰老的适用性进行实际评估。在整本书中，我们保持了轻松的基调，以便让生物老年学的非专家也能理解，并为那些考虑进行研究、研究或寻求了解抗衰老医学科学基础的人提供广泛的概述。