Oxytocin is a peptide released into brain regions associated with the processing of aversive memory and threat responses. Given the expression of oxytocin receptors across this vigilance surveillance system of the brain, we investigated whether pharmacological antagonism of the receptor would impact contextual aversive conditioning and memory. Adult male rats were conditioned to form an aversive contextual memory. The effects of peripheral administration of either the competitive antagonist Atosiban or noncompetitive antagonist L-368,899 were compared to saline controls. Oxytocin receptor antagonism treatment did not significantly impact the consolidation of aversive contextual memory in any of the groups. We conclude that peripheral antagonism of oxytocin signalling did not impact the formation of aversive memory.

中文翻译：

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雄性大鼠催产素受体拮抗作用不会损害情境恐惧记忆巩固

催产素是一种释放到与厌恶记忆和威胁反应处理相关的大脑区域的肽。鉴于催产素受体在大脑的这种警惕性监视系统中的表达，我们研究了受体的药理拮抗作用是否会影响情境厌恶调节和记忆。成年雄性大鼠被训练形成厌恶的情境记忆。将竞争性拮抗剂阿托西班或非竞争性拮抗剂 L-368,899 的外周给药效果与盐水对照进行比较。催产素受体拮抗治疗没有显着影响任何组中厌恶性情境记忆的巩固。我们的结论是，催产素信号的外周拮抗作用不会影响厌恶记忆的形成。