Tilmicosin, a macrolide antibiotic, has the potential to treat bacterial infections in donkeys. However, the pharmacokinetics of tilmicosin in donkeys have not been reported. The aim of this study was to investigate the pharmacokinetics of tilmicosin in donkey plasma, urine, and feces after a single intragastric administration to determine the suitability of tilmicosin for donkeys. A total of 5 healthy male donkeys with similar body weights were selected. The donkeys were administered a single dose of 10 mg · kg−1 body weight (BW) tilmicosin by gavage. The concentrations of tilmicosin in plasma, urine, and feces were determined. The results showed that after a single intragastric administration of 10 mg · kg−1 body weight, tilmicosin in donkey plasma reached a maximum concentration of 11.23 ± 5.37 mg · L−1 at 0.80 ± 0.10 h, with a half‐life of 14.49 ± 7.13 h, a mean residence time of 28.05 ± 3.05 h, a Cl/F of 0.48 ± 0.18 L · kg−1 · h−1, and a Vd/F of 9.28 ± 2.63 Lkg−1. The percentage of tilmicosin excreted through the urine of donkeys is 2.47%, and the percentage excreted through the feces is 66.43%. Our study provides data to inform the use of tilmicosin in donkeys.

中文翻译：

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替米考星在驴（Equus asinus）单次灌胃后血浆、尿液和粪便中的药代动力学

替米考星是一种大环内酯类抗生素，具有治疗驴细菌感染的潜力。然而，替米考星在驴体内的药代动力学尚未见报道。本研究的目的是研究单次灌胃后替米考星在驴血浆、尿液和粪便中的药代动力学，以确定替米考星对驴的适用性。共选取体重相似的健康公驴5头。驴单次给药10 mg·kg−1通过管饲法测定体重（BW）替米考星。测定血浆、尿液和粪便中替米考星的浓度。结果显示，单次灌胃10 mg·kg后−1体重时，驴血浆中替米考星最高浓度为11.23±5.37 mg·L−10.80 ± 0.10 h，半衰期为 14.49 ± 7.13 h，平均停留时间为 28.05 ± 3.05 h，Cl/F 为 0.48 ± 0.18 L·kg−1· H−1，Vd/F 为 9.28 ± 2.63 Lkg−1。驴尿中替米考星的排泄率为2.47%，粪便中的替米考星排泄率为66.43%。我们的研究提供了有关在驴中使用替米考星的数据。