BackgroundWhile preclinical studies have shown that alpha‐synuclein can spread through cell‐to‐cell transmission whether it can be transmitted between humans is unknown.ObjectivesThe aim was to assess the presence of a synucleinopathy in autopsied conjugal couples.MethodsNeuropathological findings in conjugal couples were categorized as Parkinson's disease (PD), dementia with Lewy bodies (DLB), Alzheimer's disease with Lewy bodies (ADLB), incidental Lewy body disease (ILBD), or no Lewy bodies.ResultsNinety conjugal couples were included; the mean age of death was 88.3 years; 32 couples had no Lewy bodies; 42 couples had 1 spouse with a synucleinopathy: 10 PD, 3 DLB, 13 ADLB, and 16 ILBD; 16 couples had both spouses with a synucleinopathy: in 4 couples both spouses had PD, 1 couple had PD and DLB, 4 couples had PD and ADLB, 2 couples had PD and ILBD, 1 couple had DLB and ADLB, in 3 couples both had ADLB, and 1 couple had ADLB and ILBD. No couples had both spouses with ILBD.ConclusionsThis large series of 90 autopsied conjugal couples found 16 conjugal couples with synucleinopathies, suggesting transmission of synucleinopathy between spouses is unlikely. © 2024 International Parkinson and Movement Disorder Society.

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夫妻突触核蛋白病：临床病理学研究

背景虽然临床前研究表明α-突触核蛋白可以通过细胞间传播传播，但是否可以在人与人之间传播尚不清楚。目的目的是评估尸检夫妻中是否存在突触核蛋白病。方法对夫妻中的神经病理学结果进行分类如帕金森病 (PD)、路易体痴呆 (DLB)、路易体阿尔茨海默病 (ADLB)、偶发性路易体病 (ILBD) 或无路易体。平均死亡年龄为88.3岁； 32对夫妇没有路易体； 42对夫妇中有1位配偶患有突触核蛋白病：10位PD、3位DLB、13位ADLB和16位ILBD； 16对夫妇的配偶双方均患有突触核蛋白病：4对夫妇双方均患有PD，1对夫妇患有PD和DLB，4对夫妇患有PD和ADLB，2对夫妇患有PD和ILBD，1对夫妇患有DLB和ADLB，3对夫妇都有ADLB，1 对夫妇患有 ADLB 和 ILBD。没有夫妇的配偶双方都患有 ILBD。 结论 这项对 90 对夫妻进行尸检的大型系列研究发现 16 对夫妻患有突触核蛋白病，这表明突触核蛋白病在配偶之间传播的可能性不大。 © 2024 国际帕金森和运动障碍协会。