AimHydrogels with excellent biocompatibility and biodegradability can be used as the desirable dressings for the therapy of diabetic foot ulcer (DFU). This review aimed to summarize the biological functions of hydrogels, combining with the pathogenesis of DFU.MethodsThe studies in the last 10 years were searched and summarized from the online database PubMed using a combination of keywords such as hydrogel and diabetes. The biological functions of hydrogels and their healing mechanism on DFU were elaborated.ResultsIn this review, hydrogels were classified by their active substances such as drugs, cytokines, photosensitizers, and biomimetic peptide. Based on this, the biological functions of hydrogels were summarized by associating the pathogenesis of DFU, including oxidative stress, chronic inflammation, cell phenotype change, vasculopathy, and infection. This review also pointed out some of the shortcomings of hydrogels in present researches.ConclusionsHydrogels were classified into carrier hydrogels and self‐functioning hydrogels in this review. Besides, the functions and components of existing hydrogels were clarified to provide assistance for future researches and clinical applications.image

中文翻译：

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用于糖尿病足溃疡愈合的先进多功能水凝胶：活性物质和生物功能

目的水凝胶具有优异的生物相容性和生物降解性，可作为治疗糖尿病足溃疡（DFU）的理想敷料。本文旨在结合DFU的发病机制，对水凝胶的生物学功能进行综述。方法通过在线数据库PubMed，结合水凝胶和糖尿病等关键词对近10年的研究进行检索和总结。阐述了水凝胶的生物学功能及其对糖尿病足溃疡的愈合机制。结果本文根据药物、细胞因子、光敏剂、仿生肽等活性物质对水凝胶进行分类。在此基础上，通过关联DFU的发病机制，包括氧化应激、慢性炎症、细胞表型改变、血管病变和感染，总结了水凝胶的生物学功能。本文还指出了目前水凝胶研究的一些不足。结论本文将水凝胶分为载体水凝胶和自功能水凝胶。此外，还阐明了现有水凝胶的功能和成分，为未来的研究和临床应用提供帮助。图像