Background Current guidelines recommend primary prevention statin therapy based on 10-year risk of atherosclerotic cardiovascular disease (ASCVD) assessed by the pooled cohort equations (PCE), while assessing effectiveness through low-density lipoprotein cholesterol levels. It remains uncertain whether 10-year ASCVD risk can accurately predict the mortality impact of lipid-lowering therapy.

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使用合并队列方程进行长期死亡率预测：对降脂治疗的影响

背景目前的指南推荐一级预防他汀类药物治疗，其基础是通过汇总队列方程 (PCE) 评估动脉粥样硬化性心血管疾病 (ASCVD) 的 10 年风险，同时通过低密度脂蛋白胆固醇水平评估有效性。目前尚不确定 10 年 ASCVD 风险能否准确预测降脂治疗对死亡率的影响。