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Application of the Hollow-Fiber Infection Model to Personalized Precision Dosing of Isoniazid in a Clinical Setting.
Journal of Korean Medical Science ( IF 4.5 ) Pub Date : 2024-04-08 , DOI: 10.3346/jkms.2024.39.e104
Yumi Park 1 , Pham My Tung 1, 2 , Nguyen Ky Anh 1, 2 , Yong-Soon Cho 1, 2, 3 , Jae-Gook Shin 1, 2, 3
Affiliation  

The hollow-fiber infection model (HFIM) is a valuable tool for evaluating pharmacokinetics/pharmacodynamics relationships and determining the optimal antibiotic dose in monotherapy or combination therapy, but the application for personalized precision medicine in tuberculosis treatment remains limited. This study aimed to evaluate the efficacy of adjusted antibiotic doses for a tuberculosis patient using HFIM.

中文翻译:

中空纤维感染模型在临床环境中异烟肼个体化精准给药中的应用。

中空纤维感染模型(HFIM)是评估药代动力学/药效学关系和确定单药或联合治疗中最佳抗生素剂量的宝贵工具,但个性化精准医疗在结核病治疗中的应用仍然有限。本研究旨在评估使用 HFIM 调整抗生素剂量对结核病患者的疗效。
更新日期:2024-04-08
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