Vaccination has been recommended as one of the approaches for the control of COVID-19 pandemic. However, adequate vaccine coverage is critical to the effectiveness of the vaccine at population level. Data on acceptability of the vaccine in Ugandan urban areas are limited. This study examined the prevalence, factors associated with willingness to accept COVID-19 vaccine including reasons for not taking COVID-19 vaccine in a predominantly urban population of Wakiso, central Uganda. Data were obtained from a cross-sectional study conducted between March 1st, 2021 and September 30th, 2021 in the urban population-based cohort of the Africa Medical and behavioral Sciences Organization (AMBSO). A Multivariable modified Poisson regression analysis was used to estimate adjusted prevalence ratios (aPR) and 95% confidence intervals of willingness to accept the COVID-19 vaccine. A total of 1,903 participants were enrolled in this study; 61% of whom were females. About 63% of participants indicated their willingness to accept the COVID-19 vaccine. Persons aged 13–19 years (aPR = 0.79; [95% CI: 0.74, 0.84]) or 20-29years (aPR = 0.93; [95% CI: 0.88, 0.98]) were less likely to accept the vaccine compared to persons aged 40–49 years. Persons with post-primary level of education (aPR = 1.05; [95% CI: 1.02, 1.09]) were more likely to accept the vaccine compared to persons with primary level of education. Additionally, students or individuals working in government (aPR = 1.13; [95% CI: 1.04, 1.23]) were more likely to accept the vaccine compared to individuals doing construction and Mechanic work as their main occupation. Reported reasons for not taking a COVID-19 vaccine included; concerns about side effects of the vaccine 154(57.0%), 64(23.7%) did not think the vaccines were effective, while 32(11.9%) did not like the vaccines. A substantial proportion of individuals were not willing to accept the COVID-19 vaccine. Health education campaigns on vaccination within urban communities could help reduce COVID-19 vaccine misconceptions in the urban populations more especially the young and persons with low levels of formal education.

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接受 COVID-19 疫苗的意愿、相关因素以及不接种疫苗的原因：乌干达中部瓦基索 13-80 岁人群的横断面研究

疫苗接种已被推荐作为控制 COVID-19 大流行的方法之一。然而，足够的疫苗覆盖率对于疫苗在人群层面的有效性至关重要。关于乌干达城市地区疫苗可接受性的数据有限。本研究调查了乌干达中部瓦基索主要城市人口中与接受 COVID-19 疫苗意愿相关的患病率和因素，包括不接种 COVID-19 疫苗的原因。数据来自 2021 年 3 月 1 日至 2021 年 9 月 30 日期间在非洲医学和行为科学组织 (AMBSO) 以城市人口为基础的队列中进行的一项横断面研究。使用多变量改良泊松回归分析来估计调整后的患病率 (aPR) 和接受 COVID-19 疫苗意愿的 95% 置信区间。共有 1,903 名参与者参与了这项研究；其中 61% 是女性。约 63% 的参与者表示愿意接受 COVID-19 疫苗。与普通人相比，13-19 岁（aPR = 0.79；[95% CI：0.74，0.84]）或 20-29 岁（aPR = 0.93；[95% CI：0.88，0.98]）的人接受疫苗的可能性较小年龄 40-49 岁。与小学教育程度的人相比，小学后教育程度的人（aPR = 1.05；[95% CI：1.02，1.09]）更有可能接受疫苗。此外，与以建筑和机械工作为主要职业的个人相比，在政府工作的学生或个人（aPR = 1.13；[95% CI：1.04，1.23]）更有可能接受疫苗。报告的不接种 COVID-19 疫苗的原因包括：担心疫苗副作用 154人(57.0%)，64人(23.7%)不认为疫苗有效，32人(11.9%)不喜欢疫苗。很大一部分人不愿意接受 COVID-19 疫苗。在城市社区内开展疫苗接种健康教育活动有助于减少城市人口，尤其是年轻人和正规教育水平较低的人对 COVID-19 疫苗的误解。