The tumor microenvironment (TME) and interleukin-22 (IL-22) in cytokines have recently attracted much attention due to their potential impact on tumor biology. However, the role of IL-22 in triple negative breast cancer (TNBC) TME is still poorly understood. This article investigated the gene expression and function of IL-22 in TNBC TME. Tumor samples from TNBC patients were collected, and adjacent noncancerous tissues were used as controls. A functional test was performed to evaluate the impact of IL-22 for TNBC cells, including proliferation, migration, and apoptosis. IL-22 gene expression in TNBC tumor samples was markedly higher relative to adjacent non-cancerous tissues ( 0.05). In addition, it was also observed that IL-22facilitated proliferation and migration of TNBC cells, and inhibit apoptosis. This article reveals the role of IL-22 in the TME of TNBC. The up-regulation of IL-22 gene expression in TNBC tumors and its promoting effect on cancer cell invasiveness highlight its potential as a therapeutic target in TNBC treatment strategies. The findings suggested that targeting IL-22 and its related pathways can offer new insights for developing effective therapies for TNBC.

中文翻译：

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细胞因子白细胞介素22基因在三阴性乳腺癌肿瘤微环境中的表达及功能

肿瘤微环境（TME）和细胞因子中的白细胞介素22（IL-22）因其对肿瘤生物学的潜在影响而最近引起了广泛关注。然而，IL-22 在三阴性乳腺癌 (TNBC) TME 中的作用仍知之甚少。本文研究了 TNBC TME 中 IL-22 的基因表达和功能。收集 TNBC 患者的肿瘤样本，并使用邻近的非癌组织作为对照。进行功能测试以评估 IL-22 对 TNBC 细胞的影响，包括增殖、迁移和凋亡。 TNBC 肿瘤样本中的 IL-22 基因表达明显高于邻近非癌组织 (0.05)。此外，还观察到IL-22促进TNBC细胞的增殖和迁移，并抑制细胞凋亡。本文揭示了IL-22在TNBC TME中的作用。 TNBC 肿瘤中 IL-22 基因表达的上调及其对癌细胞侵袭性的促进作用凸显了其作为 TNBC 治疗策略中治疗靶点的潜力。研究结果表明，针对 IL-22 及其相关通路可以为开发 TNBC 的有效疗法提供新的见解。