Biomarkers are biochemical indicators that can identify changes in the structure or function of systems, organs, or cells and can be used to monitor a wide range of biological processes, including cancer. Interleukin-1 receptor antagonist (IL1RA) is an important inflammatory suppressor gene and tumor biomarker. The goal of this study was to investigate the expression of IL1RA, its probable carcinogenic activity, and its diagnostic targets in oral squamous cell carcinoma (OSCC). We discovered that IL1RA was expressed at a low level in OSCC tumor tissues compared to normal epithelial tissues and that the expression declined gradually from epithelial hyperplasia through dysplasia to carcinoma in situ and invasive OSCC. Low IL1RA expression was associated not only with poor survival but also with various clinicopathological markers such as increased infiltration, recurrence, and fatalities. Following cellular phenotyping investigations in OSCC cells overexpressing IL1RA, we discovered that recovering IL1RA expression decreased OSCC cell proliferation, migration, and increased apoptosis. In summary, our investigation highlighted the possible involvement of low-expression IL1RA in OSCC cells in promoting invasive as well as metastatic and inhibiting apoptosis, as well as the efficacy of IL1RA-focused monitoring in the early detection and treatment of OSCC.

中文翻译：

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IL-1受体拮抗剂的低表达通过促进口腔鳞状细胞癌的增殖和迁移并抑制细胞凋亡与不良预后相关

生物标志物是一种生化指标，可以识别系统、器官或细胞的结构或功能的变化，可用于监测包括癌症在内的多种生物过程。白介素1受体拮抗剂（IL1RA）是一种重要的炎症抑制基因和肿瘤生物标志物。本研究的目的是研究口腔鳞状细胞癌 (OSCC) 中 IL1RA 的表达、其可能的致癌活性及其诊断靶点。我们发现，与正常上皮组织相比，IL1RA在OSCC肿瘤组织中表达水平较低，并且表达从上皮增生、不典型增生到原位癌和侵袭性OSCC逐渐下降。 IL1RA 低表达不仅与生存率低相关，还与各种临床病理标志物相关，例如浸润、复发和死亡增加。在对过度表达 IL1RA 的 OSCC 细胞进行细胞表型研究后，我们发现恢复 IL1RA 表达会减少 OSCC 细胞的增殖、迁移并增加凋亡。总之，我们的研究强调了 OSCC 细胞中低表达 IL1RA 可能参与促进侵袭性和转移以及抑制细胞凋亡，以及以 IL1RA 为重点的监测在 OSCC 早期检测和治疗中的功效。