Pd(OAc)₂/Nixantphos or CoI₂/Nixantphos catalyzed allylic substitutions with weakly acidic C(sp)³–H bonds of azaarylmethylamines are described. This method facilitates access to various kinds of heteroaryl rings containing homoallylamines (39 examples, 30–98% yields) with excellent functional group tolerance and diastereoselectivity. Compared with the Pd/Nixantphos complex, the Co/Nixantphos catalysis could obtain the cyclic products with good to excellent diastereoselectivities. Importantly, the CoI₂/(R,R)-Me-Duphos catalyzed reactions exhibit moderate enantioselectivity. Additionally, the scalability of this transformation is successfully demonstrated.

中文翻译：

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钴或钯催化氮杂芳基甲基胺的烯丙基取代合成高烯丙胺

描述了Pd(OAc) ₂ /Nixantphos 或 CoI ₂ /Nixantphos 催化的氮杂芳基甲基胺的弱酸性 C(sp) ³ –H 键的烯丙基取代。该方法有利于获得各种含有高烯丙胺的杂芳环（39 个例子，产率 30-98%），具有优异的官能团耐受性和非对映选择性。与Pd/Nixantphos配合物相比，Co/Nixantphos催化可以获得具有良好至优异非对映选择性的环状产物。重要的是，CoI ₂ /( R,R )-Me-Duphos 催化反应表现出中等的对映选择性。此外，这种转变的可扩展性也得到了成功的证明。