Non-alcoholic fatty liver disease (NAFLD) has become the most frequent liver disease, closely related with metabolic risk factors such as obesity, insulin resistance, dyslipidemia, diabetes mellitus, and metabolic syndrome. In this context, γ-Glutamyl transpeptidase (GGT) and high-density lipoprotein cholesterol (HDL-C) have shown correlations with steatosis severity and metabolic syndrome, respectively. This positions the GGT/HDL-C ratio as a potential diagnostic indicator for NAFLD. To assess the diagnostic performance of the GGT/HDL-C ratio for NAFLD in adults with obesity undergoing bariatric surgery. We conducted an analytical cross-sectional study, designed as a diagnostic test evaluation. A secondary database of 249 adults with obesity was analyzed. The optimal cut-off point was ascertained using three methodologies, and five adjustment models were constructed for the total population, further stratified by sex. The optimal cut-off point was 20.5 U/mmol and the AUC of the ratio was 0.81 (95% CI: 0.64–0.98), with sensitivity and specificity being 82.5% and 77.8%, respectively. In the overall group with an elevated GGT/HDL-C ratio, the prevalence of NAFLD increased by 14% (PR: 1.14; 95% CI: 1.04–1.33). Specifically, women displaying this altered ratio showed a 19% increased prevalence (PR: 1.19; 95% CI: 1.07–1.42) compared to those with normal values. The GGT/HDL-C ratio is a promising biomarker for the diagnosis of NAFLD in an adult population living with obesity

中文翻译：

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GGT/HDL-C 比值对接受减肥手术的肥胖成人 NAFLD 的诊断性能

非酒精性脂肪肝病（NAFLD）已成为最常见的肝脏疾病，与肥胖、胰岛素抵抗、血脂异常、糖尿病和代谢综合征等代谢危险因素密切相关。在这种情况下，γ-谷氨酰转肽酶 (GGT) 和高密度脂蛋白胆固醇 (HDL-C) 分别与脂肪变性严重程度和代谢综合征相关。这使得 GGT/HDL-C 比率成为 NAFLD 的潜在诊断指标。评估 GGT/HDL-C 比值对接受减肥手术的肥胖成人 NAFLD 的诊断性能。我们进行了一项分析横断面研究，旨在作为诊断测试评估。对 249 名肥胖成人的二级数据库进行了分析。使用三种方法确定了最佳截止点，并为总人口构建了五种调整模型，并按性别进一步分层。最佳截点为20.5 U/mmol，比率的AUC为0.81（95% CI：0.64-0.98），敏感性和特异性分别为82.5%和77.8%。在 GGT/HDL-C 比值升高的总体组中，NAFLD 的患病率增加了 14%（PR：1.14；95% CI：1.04–1.33）。具体来说，与正常值的女性相比，表现出这种比例改变的女性患病率增加了 19%（PR：1.19；95% CI：1.07-1.42）。 GGT/HDL-C 比值是诊断肥胖成年人 NAFLD 的一个有前途的生物标志物