C-type lectin receptors (CLRs) expressed by myeloid cells constitute a versatile family of receptors that play a key role in innate immune recognition. Myeloid CLRs exhibit a remarkable ability to recognize an extensive array of ligands, from carbohydrates and beyond, and encompass pattern-associated molecular patterns (PAMPs), damage-associated molecular patterns (DAMPs), and markers of altered self. These receptors, classified into distinct subgroups, play pivotal roles in immune recognition and modulation of immune responses. Their intricate signaling pathways orchestrate a spectrum of cellular responses, influencing processes such as phagocytosis, cytokine production, and antigen presentation. Beyond their contributions to host defense in viral, bacterial, fungal, and parasitic infections, myeloid CLRs have been implicated in non-infectious diseases such as cancer, allergies, and autoimmunity. A nuanced understanding of myeloid CLR interactions with endogenous and microbial triggers is starting to uncover the context-dependent nature of their roles in innate immunity, with implications for therapeutic intervention.

中文翻译：

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先天免疫识别中的骨髓C型凝集素受体

骨髓细胞表达的 C 型凝集素受体 (CLR) 构成了一个多功能受体家族，在先天免疫识别中发挥着关键作用。骨髓 CLR 表现出非凡的能力，可以识别来自碳水化合物等的广泛配体，并涵盖模式相关分子模式 (PAMP)、损伤相关分子模式 (DAMP) 和自我改变的标记。这些受体分为不同的亚组，在免疫识别和免疫反应调节中发挥着关键作用。它们复杂的信号通路协调一系列细胞反应，影响吞噬作用、细胞因子产生和抗原呈递等过程。除了在病毒、细菌、真菌和寄生虫感染中对宿主防御做出贡献之外，骨髓 CLR 还与癌症、过敏和自身免疫等非传染性疾病有关。对骨髓 CLR 与内源性和微生物触发因素相互作用的细致了解开始揭示它们在先天免疫中的作用的背景依赖性性质，这对治疗干预具有影响。