Five new cytochalasins, diaporchalasins A−E (1−5), together with 14 known congeners (6−19) were isolated from the endophytic fungus Diaporthe sp. BMX12, which was isolated from the branches of Aquilaria sinensis. The structures of the new compounds were elucidated by extensive spectroscopic analyses including high‐resolution electron spray ionization mass spectrometry (HRESIMS) and nuclear magnetic resonance (NMR). Their absolute configurations were assigned by theoretical electronic circular dichroism (ECD) calculations. Compounds 11 and 12 featuring a keto carbonyl at C‐21 displayed cytotoxicity toward K562, BEL‐7402, SGC‐7901, A549, and HeLa cell lines with IC50 values ranging from 4.4 to 47.4 μM.

中文翻译：

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Diaporchalasins A−E，来自内生真菌 Diaporthe sp 的新细胞松弛素。从沉香中分离出 BMX12

从内生真菌 Diaporthe sp 中分离出 5 种新的细胞松弛素，diaporchalasins A−E (1−5)，以及 14 种已知的同源物 (6−19)。 BMX12，从白木香的枝条中分离出来。通过广泛的光谱分析，包括高分辨率电子喷雾电离质谱（HRESIMS）和核磁共振（NMR），阐明了新化合物的结构。它们的绝对构型是通过理论电子圆二色性（ECD）计算来确定的。在 C-21 处具有酮羰基的化合物 11 和 12 对 K562、BEL-7402、SGC-7901、A549 和 HeLa 细胞系表现出细胞毒性，IC50 值范围为 4.4 至 47.4 μM。