Chromosomal instability (CIN), caused by errors in the segregation of chromosomes during mitosis, is a hallmark of many types of cancer. The fidelity of chromosome segregation is governed by a sophisticated cellular signaling network, one crucial orchestrator of which is Heterochromatin protein 1 (HP1). HP1 dynamically localizes to distinct sites at various stages of mitosis, where it regulates key mitotic events ranging from chromosome–microtubule attachment to sister chromatid cohesion to cytokinesis. Our evolving comprehension of HP1's multifaceted role has positioned it as a central protein in the orchestration of mitotic processes.

中文翻译：

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HP1 预防染色体不稳定的功能

染色体不稳定（CIN）是由有丝分裂过程中染色体分离错误引起的，是许多类型癌症的一个标志。染色体分离的保真度由复杂的细胞信号网络控制，其中一个关键的协调器是异染色质蛋白 1 (HP1)。 HP1 动态定位于有丝分裂各个阶段的不同位点，调节关键的有丝分裂事件，从染色体-微管附着到姐妹染色单体凝聚再到胞质分裂。我们对 HP1 多方面作用的不断理解已将其定位为有丝分裂过程协调中的中心蛋白。