Phenethyl isothiocyanate (PEITC), a compound derived from cruciferous vegetables, has garnered attention for its anticancer properties. This review synthesizes existing research on PEITC, focusing on its mechanisms of action in combatting cancer. PEITC has been found to be effective against various cancer types, such as breast, prostate, lung, colon, and pancreatic cancers. Its anticancer activities are mediated through several mechanisms, including the induction of apoptosis (programmed cell death), inhibition of cell proliferation, suppression of angiogenesis (formation of new blood vessels that feed tumors), and reduction of metastasis (spread of cancer cells to new areas). PEITC targets crucial cellular signaling pathways involved in cancer progression, notably the Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB), Protein Kinase B (Akt), and Mitogen-Activated Protein Kinase (MAPK) pathways. These findings suggest PEITC's potential as a therapeutic agent against cancer. However, further research is necessary to determine the optimal dosage, understand its bioavailability, and assess potential side effects. This will be crucial for developing PEITC-based treatments that are both effective and safe for clinical use in cancer therapy.

中文翻译：

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异硫氰酸苯乙酯的营养来源和抗癌潜力：分子机制和治疗见解

异硫氰酸苯乙酯 (PEITC) 是一种从十字花科蔬菜中提取的化合物，因其抗癌特性而受到关注。本综述综合了 PEITC 的现有研究，重点关注其抗癌作用机制。 PEITC 已被发现可有效对抗多种癌症类型，如乳腺癌、前列腺癌、肺癌、结肠癌和胰腺癌。其抗癌活性通过多种机制介导，包括诱导细胞凋亡（程序性细胞死亡）、抑制细胞增殖、抑制血管生成（形成为肿瘤提供营养的新血管）和减少转移（癌细胞扩散到新的细胞）。地区）。 PEITC 靶向参与癌症进展的关键细胞信号传导通路，特别是活化 B 细胞的核因子 kappa 轻链增强子 (NF-κB)、蛋白激酶 B (Akt) 和丝裂原激活蛋白激酶 (MAPK) 通路。这些发现表明 PEITC 作为癌症治疗剂的潜力。然而，还需要进一步的研究来确定最佳剂量、了解其生物利用度并评估潜在的副作用。这对于开发基于 PEITC 的治疗方法至关重要，这种治疗方法对于临床癌症治疗来说既有效又安全。