The aim of this study was to explore the correlation between biomarkers of lipid metabolism and gastric cancer. 1120 gastric cancer patients and 1134 health examiners enrolled in this study. The clinic data and serum lipid level, including Total cholesterol (TC), Triglyceride (TG), Low-density lipoprotein cholesterol (LDL-C) and High-density lipoprotein cholesterol (HDL-C), were collected. Serum TG and LDL-C levels in patients with gastric cancer were higher than those in the control group. HDL-C levels were lower than the control group (P < 0.05). HDL-C and LDL-C were significantly correlated with the risk of gastric cancer. Concentrating on clinicopathological features, increased TG was more frequently in male patients with distal gastric cancer, N0 stage and early TNM stage. Increased TC was more frequently in early T, N and TNM stage. Decreased HDL-C was more common in distal location and low-undifferentiated gastric cancer. LDL-C elevation was more common in distal gastric cancer and early T stage. The serum lipid level of gastric cancer patients was higher than healthy controls. HDL-C and LDL-C abnormal correlated with gastric cancer risk. However, as the progresses of gastric cancer, poor patient intake, increased tumor consumption, and continuous declining in nutritional status, the levels of TC and TG gradually decreased in advanced gastric cancer.

中文翻译：

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胃癌脂质代谢的生物标志物：病例对照研究

本研究旨在探讨脂质代谢生物标志物与胃癌之间的相关性。 1120 名胃癌患者和 1134 名体检人员参加了这项研究。收集临床资料和血脂水平，包括总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）。胃癌患者血清TG、LDL-C水平高于对照组。 HDL-C水平低于对照组（P < 0.05）。 HDL-C和LDL-C与胃癌风险显着相关。从临床病理特征来看，TG升高在男性远端胃癌、N0期和早期TNM分期患者中更为常见。 TC升高在早期T、N和TNM阶段更为常见。 HDL-C降低在远端位置和低未分化胃癌中更为常见。 LDL-C升高在远端胃癌和早期T期中更为常见。胃癌患者的血脂水平高于健康对照者。 HDL-C 和 LDL-C 异常与胃癌风险相关。但随着胃癌的进展，患者摄入不良，肿瘤消耗增加，营养状况持续下降，进展期胃癌TC、TG水平逐渐下降。