The present study investigated drug-loaded, titanium alloy (Ti6Al4V) graded porous structure with desired mechanical properties for implant-based local drug delivery application. The fabricated graded porous metallic structures displayed compressive yield strength in a range of 110.8–283.8 MPa, open porosity 30.2–69.4% and Young’s modulus 2.2–12.1 GPa. These characteristics resemble the range for human bone tissue. The electrochemical corrosion behaviour of the fabricated structures was found satisfactory even though comparatively higher corrosion rate was observed in porous samples. The analysis showed the formation of protective passive layer on the exposed surface of the porous samples. The micrographs confirmed the presence of well-distributed interconnected pores in the peripheral region of the samples which were used to load drug (simvastatin) using different dispersion media. It was found that by varying the later, the in vitro release of loaded drug can be prolonged to as long as 14 days.

Graphical abstract

中文翻译：

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用于承载生物医学应用的载药梯度多孔 Ti6Al4V 结构的制造

本研究研究了载药钛合金 (Ti6Al4V) 分级多孔结构，该结构具有基于植入物的局部药物输送应用所需的机械性能。制造的分级多孔金属结构的压缩屈服强度在110.8-283.8 MPa范围内，开孔率在30.2-69.4%范围内，杨氏模量在2.2-12.1 GPa范围内。这些特征类似于人体骨组织的范围。尽管在多孔样品中观察到相对较高的腐蚀速率，但所制造的结构的电化学腐蚀行为令人满意。分析表明在多孔样品的暴露表面上形成了保护性钝化层。显微照片证实了样品外围区域存在分布均匀的互连孔，这些孔用于使用不同的分散介质负载药物（辛伐他汀）。结果发现，通过改变后者，负载药物的体外释放可以延长至长达14天。

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