The relationships between maternal exposure to endocrine-disrupting chemicals (EDCs) and congenital heart diseases (CHD) are not elucidated yet. The exposure levels of EDCs are generally estimated based on self-reported questionnaires or occupational exposure evaluations in the literature. Therefore, a study based on epidemiological data from human biospecimens is required to provide stronger evidence between maternal exposure to EDC and CHD. Embase, Pubmed, Scopus, and the Cochrane Library databases were searched for related research which provided risk estimates regarding the relationships between maternal EDC exposure and CHD in human offspring. Baseline characteristics and outcomes of CHD were extracted from each included study. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled to calculate the overall estimates of CHD. Subgroup and meta-regression analyses were performed to identify the sources of heterogeneity. Bootstrapping techniques were used in analyses where several studies originated from a similar population. A total of seventeen studies were involved in the meta-analyses. Maternal EDC exposure was significantly related to CHD in offspring (OR 2.15; 95%CI 1.64 to 2.83). EDC exposure was significantly associated with septal defects (OR 2.34; 95%CI 1.77 to 3.10), conotruncal defects (OR 2.54; 95%CI 1.89 to 3.43), right ventricular outflow tract obstruction (OR 2.65; 95%CI 1.73 to 4.07), left ventricular outflow tract obstruction (OR 3.58; 95%CI 2.67 to 4.79), anomalous pulmonary venous return (OR 2.31; 95%CI 1.34 to 4.00), and other heart defects (OR 2.49; 95%CI 1.75 to 3.54). In addition, maternal exposure to heavy metals, which included lead (OR 2.19; 95%CI 1.29 to 3.71), cadmium (OR 1.81; 95%CI 1.28 to 2.56), mercury (OR 2.23; 95%CI 1.13 to 4.44), and manganese (OR 2.65; 95%CI 1.48 to 4.74), increased risks for CHD significantly. In conclusion, based on the latest evidence, maternal EDC exposure may increase CHD risks in human offspring, especially in heavy metal exposure conditions.

母亲接触内分泌干扰化学物质 (EDC) 与先天性心脏病 (CHD) 之间的关系尚未阐明。 EDC的暴露水平通常根据自我报告的问卷或文献中的职业暴露评估来估计。因此，需要开展一项基于人类生物样本流行病学数据的研究，以提供母亲接触 EDC 和 CHD 之间更有力的证据。检索了 Embase、Pubmed、Scopus 和 Cochrane 图书馆数据库中的相关研究，这些研究提供了有关母亲 EDC 暴露与人类后代 CHD 之间关系的风险估计。从每项纳入的研究中提取了 CHD 的基线特征和结果。将比值比 (OR) 与 95% 置信区间 (CI) 合并起来计算 CHD 的总体估计值。进行亚组和荟萃回归分析以确定异质性的来源。引导技术用于分析，其中几项研究源自相似的人群。荟萃分析总共涉及十七项研究。母亲 EDC 暴露与后代 CHD 显着相关（OR 2.15；95%CI 1.64 至 2.83）。 EDC暴露与室间隔缺损（OR 2.34；95%CI 1.77至3.10）、圆锥干缺损（OR 2.54；95%CI 1.89至3.43）、右心室流出道梗阻（OR 2.65；95%CI 1.73至4.07）显着相关、左心室流出道梗阻（OR 3.58；95%CI 2.67至4.79）、肺静脉回流异常（OR 2.31；95%CI 1.34至4.00）和其他心脏缺陷（OR 2.49；95%CI 1.75至3.54）。此外，母亲接触的重金属包括铅（OR 2.19；95%CI 1.29至3.71）、镉（OR 1.81；95%CI 1.28至2.56）、汞（OR 2.23；95%CI 1.13至4.44）、和锰（OR 2.65；95%CI 1.48至4.74），显着增加CHD风险。总之，根据最新证据，母亲 EDC 暴露可能会增加人类后代的 CHD 风险，尤其是在重金属暴露条件下。