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Alumina Ceramic Textiles as Novel Bacteria‐Capturing Wound Dressings
Advanced Materials Interfaces ( IF 5.4 ) Pub Date : 2024-04-12 , DOI: 10.1002/admi.202400232
Deepanjalee Dutta 1 , Renato S. M. Almeida 1 , Md Nurul Karim 1 , Dorothea Brüggemann 2 , Kurosch Rezwan 1, 3 , Michael Maas 1, 3
Affiliation  

Although antimicrobial dressings have proven to be crucial in the treatment of wounds, they may give rise to antibiotic‐resistant strains or result in the release of endotoxins after bacterial death, which in turn inhibits wound healing. This study highlights the efficacy of a novel alumina ceramic textile as dressing that utilizes the principles of bacteria capture from the wound bed and inhibition of bacterial infiltration into the wound bed to reduce the bacterial burden and to inhibit the spread of infection, without the involvement of active antimicrobial substances or functional nanoparticles. The alumina textiles are compared to commercial dressings like the non‐woven mesh Cutimed Sorbact and gauzes from LEINA WERKE and performed significantly better in capturing bacteria. They are found to be effective against both Gram‐negative Escherichia coli and Gram‐positive Bacillus subtilis and show promising results in the presence of simulated wound fluid and in artificial wound bed tests from which they can be easily lifted without leaving behind any visible residues. In summary, the alumina textiles exhibit a highly efficient bacterial binding activity, possibly due to the intrinsic material properties of their hierarchical structure including the tricot knit mesh, small fiber diameters, pronounced fiber surface microtopography, and high specific surface area.

中文翻译:

氧化铝陶瓷纺织品作为新型细菌捕获伤口敷料

尽管抗菌敷料已被证明在伤口治疗中至关重要,但它们可能会产生抗生素耐药菌株或导致细菌死亡后释放内毒素,进而抑制伤口愈合。这项研究强调了新型氧化铝陶瓷织物作为敷料的功效,它利用从伤口床捕获细菌并抑制细菌渗入伤口床的原理来减少细菌负荷并抑制感染传播,而无需参与活性抗菌物质或功能性纳米颗粒。与 LEINA WERKE 的无纺网状 Cutimed Sorbact 和纱布等商用敷料相比,氧化铝纺织品在捕获细菌方面表现明显更好。发现它们对革兰氏阴性菌有效大肠杆菌和革兰氏阳性枯草芽孢杆菌并在模拟伤口液存在和人工伤口床测试中显示出有希望的结果,可以轻松地将它们提起而不会留下任何可见的残留物。总之,氧化铝纺织品表现出高效的细菌结合活性,这可能是由于其分层结构的固有材料特性,包括经编针织网、小纤维直径、明显的纤维表面微形貌和高比表面积。
更新日期:2024-04-12
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