Establishing direct reference intervals (RIs) for paediatric patients is a very challenging endeavour. Indirect RIs can address this problem, using existing clinical laboratory databases from real-world data research. Compared to the traditional direct method, the indirect approach is highly practical, widely applicable, and low-cost. Considering the relevance of dyslipidemia in the paediatric age, to provide better laboratory services to the local paediatric population, we established population-specific lipid RIs via data mining.

中文翻译：

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血浆脂质儿科参考区间：使用 14 年大型数据库进行间接估计。

为儿科患者建立直接参考区间 (RI) 是一项非常具有挑战性的工作。间接 RI 可以利用来自现实世界数据研究的现有临床实验室数据库来解决这个问题。与传统的直接法相比，间接法实用性强、适用范围广、成本低。考虑到血脂异常与儿科年龄的相关性，为了给当地儿科人群提供更好的实验室服务，我们通过数据挖掘建立了人群特异性血脂RI。