Isoniazid and streptomycin are vital drugs for treating tuberculosis, which are utilized as efficient anti-tuberculosis agents. This paper presents a novel visible-light-driven composite photocatalyst Ti₃C₂/Bi/BiOI, which was built from Ti₃C₂ nanosheets and Bi/BiOI microspheres. Photoelectrochemical (PEC) sensors based on Ti₃C₂/Bi/BiOI were synthesized for isoniazid identification, which showed a linear concentration range of 0.1–125 μM with a detection limit of 0.05 μM (S/N = 3). Moreover, we designed a PEC aptasensors based on aptamer/Ti₃C₂/Bi/BiOI to detect streptomycin in 0.1 M PBS covering the electron donor isoniazid, because the isoniazid consumes photogenerated holes thus increasing the photocurrent effectively and preventing photogenerated electron–hole pairs from being recombined. Furthermore, PEC aptasensors based on aptamer/Ti₃C₂/Bi/BiOI were synthesized for streptomycin identification, which exhibited a linear concentration range of 0.01–1000 nM with a detection limit of 2.3 × 10^-3 nM (S/N = 3), and are well stable in streptomycin sensing.

Graphical Abstract

中文翻译：

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基于 Ti3C2 异质结构书形层上生长的金属 Bi 掺杂 BiOI 微球的异烟肼和链霉素光电化学传感

异烟肼和链霉素是治疗结核病的重要药物，是有效的抗结核药物。本文提出了一种新型可见光驱动复合光催化剂Ti ₃ C _{2 /Bi/BiOI，它由Ti 3} C ₂纳米片和Bi/BiOI微球构成。合成了基于Ti ₃ C ₂ /Bi/BiOI的光电化学（PEC）传感器用于异烟肼鉴定，其线性浓度范围为0.1-125 μM，检测限为0.05 μM（S/N = 3）。此外，我们设计了一种基于适体/Ti ₃ C ₂ /Bi/BiOI的PEC适体传感器，用于检测覆盖电子供体异烟肼的0.1 M PBS中的链霉素，因为异烟肼消耗光生空穴，从而有效地增加光电流并防止光生电子空穴对免于重新组合。此外，合成了基于适体/Ti ₃ C ₂ /Bi/BiOI的PEC适体传感器用于链霉素鉴定，其线性浓度范围为0.01–1000 nM，检测限为2.3 × 10 ^-3 nM (S/N = 3 ），并且在链霉素传感中非常稳定。

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