In conjunction with theoretical calculations, the in vitro and in vivo uranyl binding capabilities of a bidentate picolinate (Pic) ligand and its pentadentate derivative (H₂dpa) are investigated. The planar N₃O₂-donor configuration of H₂dpa matches the typical pentagonal-bipyramid coordination geometry of uranyl, demonstrating a remarkable removal preference for uranyl in the kidneys.

中文翻译：

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通过基于吡啶甲酸的五齿螯合剂从肾脏中有效去除铀

结合理论计算，研究了二齿吡啶甲酸( Pic )配体及其五齿衍生物( H ₂ dpa )的体外和体内铀酰结合能力。 H ₂ dpa的平面 N ₃ O ₂供体构型与铀酰的典型五角双锥配位几何形状相匹配，表明肾脏对铀酰具有显着的去除偏好。