The Hippo signalling pathway, an evolutionarily conserved kinase cascade, has been shown to be crucial for cell fate determination, homeostasis and tissue regeneration. Recent experimental and clinical studies have demonstrated that the Hippo signalling pathway is involved in the pathophysiology of ocular diseases. This article provides the first systematic review of studies on the regulatory and functional roles of mammalian Hippo signalling systems in eye diseases. More comprehensive studies on this pathway are required for a better understanding of the pathophysiology of eye diseases and the development of effective therapies.

中文翻译：

---

Hippo信号通路及其对眼部疾病的影响

Hippo 信号通路是一种进化上保守的激酶级联，已被证明对于细胞命运决定、体内平衡和组织再生至关重要。最近的实验和临床研究表明，Hippo信号通路参与眼部疾病的病理生理学。本文首次对哺乳动物河马信号系统在眼部疾病中的调节和功能作用的研究进行了系统综述。为了更好地了解眼部疾病的病理生理学和开发有效的治疗方法，需要对该途径进行更全面的研究。