Liposomes—microscopic phospholipid bubbles with bilayered membrane structure—have been a focal point in drug delivery research for the past 30 years. Current liposomes possess a blend of biocompatibility, drug loading efficiency, prolonged circulation and targeted delivery. Tailored liposomes, varying in size, charge, lipid composition, and ratio, have been developed to address diseases in specific organs, thereby enhancing drug circulation, accumulation at lesion sites, intracellular delivery, and treatment efficacy for various organ-specific diseases. For further successful development of this field, this review summarized liposomal strategies for targeting different organs in series of major human diseases, including widely studied cardiovascular diseases, liver and spleen immune diseases, chronic or acute kidney injury, neurodegenerative diseases, and organ-specific tumors. It highlights recent advances of liposome-mediated therapeutic agent delivery for disease intervention and organ rehabilitation, offering practical guidelines for designing organ-targeted liposomes.

中文翻译：

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脂质体在器官靶向治疗中的应用策略

脂质体（具有双层膜结构的微观磷脂泡）在过去 30 年一直是药物递送研究的焦点。目前的脂质体兼具生物相容性、载药效率、延长循环和靶向递送等优点。定制的脂质体具有不同的大小、电荷、脂质成分和比例，已被开发用于解决特定器官的疾病，从而增强药物循环、在病变部位的积累、细胞内递送和对各种器官特异性疾病的治疗功效。为了该领域的进一步成功发展，本文总结了一系列人类重大疾病中针对不同器官的脂质体策略，包括广泛研究的心血管疾病、肝脾免疫疾病、慢性或急性肾损伤、神经退行性疾病和器官特异性肿瘤。它强调了脂质体介导的治疗剂递送用于疾病干预和器官康复的最新进展，为设计器官靶向脂质体提供了实用指南。