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Impulse Control Disorders in Parkinson’s Disease: An Overview of Risk Factors, Pathogenesis and Pharmacological Management
CNS Drugs ( IF 6 ) Pub Date : 2024-04-13 , DOI: 10.1007/s40263-024-01087-y
Federico Carbone , Atbin Djamshidian

Impulse control disorders in Parkinson’s disease are relatively common drug-induced addictive behaviours that are usually triggered by the dopamine agonists pramipexole, ropinirole and rotigotine. This narrative review aimed to provide a comprehensive overview of the current knowledge of impulse control disorders in Parkinson’s disease. We summarised the prevalence, clinical features, risk factors and potential underlying mechanisms of impulse control disorders in Parkinson’s disease. Moreover, recent advances in behavioural and imaging characteristics and management strategies are discussed. Early detection as well as a tailored multidisciplinary approach, which typically includes careful adjustment of the dopaminergic therapy and the treatment of associated neuropsychiatric symptoms, are necessary. In some cases, a continuous delivery of levodopa via a pump or the dopamine D1 receptor agonist, apomorphine, can be considered. In selected patients without cognitive or speech impairment, deep brain stimulation of the subthalamic nucleus can also improve addictions. Finding the right balance of tapering dopaminergic dose (usually dopamine agonists) without worsening motor symptoms is essential for a beneficial long-term outcome.



中文翻译:

帕金森病的冲动控制障碍:危险因素、发病机制和药理学管理概述

帕金森病中的冲动控制障碍是相对常见的药物引起的成瘾行为,通常由多巴胺激动剂普拉克索、罗匹尼罗和罗替戈汀引发。这篇叙述性综述旨在全面概述帕金森病冲动控制障碍的当前知识。我们总结了帕金森病冲动控制障碍的患病率、临床特征、危险因素和潜在的潜在机制。此外,还讨论了行为和成像特征以及管理策略的最新进展。早期检测以及量身定制的多学科方法(通常包括仔细调整多巴胺能治疗和治疗相关神经精神症状)是必要的。在某些情况下,可以考虑通过泵连续输送左旋多巴或多巴胺 D 1受体激动剂阿扑吗啡。在某些没有认知或言语障碍的患者中,丘脑底核的深部脑刺激也可以改善成瘾症状。在不恶化运动症状的情况下找到逐渐减少多巴胺能剂量(通常是多巴胺激动剂)的正确平衡对于获得有益的长期结果至关重要。

更新日期:2024-04-13
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