BACKGROUND:The adsorption of activated charcoal is currently a major clinical treatment for acute organophosphorus pesticide poisoning (AOPP). However, the adsorption duration and efficiency of this method is unstable. OBJECTIVE:In this study, a hydrogel embedding activated charcoal was prepared and its alleviating effects on AOPP were investigated. METHODS:A composite hydrogel using sodium alginate and polyvinyl alcohol (SA-PVA) hydrogel was prepared in this study. The structural properties of the SA-PVA hydrogel were characterized via multiple analysis including FTIR, TGA, XRD, SEM, tensile strength and expansion rate. Based on these, activated charcoal (AC) was embedded within the SA-PVA hydrogel (SA-PVA-AC) and it was used for the treatment of AOPP. RESULTS:Structural characterization indicated SA-PVA hydrogel possesses excellent mechanical properties and biocompatibility. The in vivo study demonstrated that SA-PVA-AC significantly alleviated the inflammation and oxidative damage in the liver, as evidenced by reduced levels of IL-6, TNF-α, and, IL-1β, SOD, and MDA. Furthermore, SA-PVA-AC treatment effectively re-regulated the activities of serum AST and ALT, exhibiting an improved effect on liver function. CONCLUSION:The findings suggest that activated charcoal embedded within SA-PVA hydrogel has significant potential as a therapeutic agent in treating AOPP, and offering a novel approach to managing pesticide-induced toxicity.

中文翻译：

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活性炭包埋海藻酸钠-聚乙烯醇水凝胶强化治疗急性有机磷农药中毒

背景：活性炭吸附是目前临床治疗急性有机磷农药中毒（AOPP）的主要方法。但该方法的吸附持续时间和效率不稳定。目的：制备水凝胶包埋活性炭并探讨其对AOP​​P的缓解作用。方法:本研究制备了海藻酸钠和聚乙烯醇(SA-PVA)水凝胶的复合水凝胶。通过 FTIR、TGA、XRD、SEM、拉伸强度和膨胀率等多种分析对 SA-PVA 水凝胶的结构性能进行了表征。在此基础上，将活性炭（AC）嵌入SA-PVA水凝胶（SA-PVA-AC）中，用于治疗AOPP。结果：结构表征表明SA-PVA水凝胶具有优异的力学性能和生物相容性。体内研究表明，SA-PVA-AC 显着减轻肝脏炎症和氧化损伤，IL-6、TNF-α、IL-1β、SOD 和 MDA 水平降低就证明了这一点。此外，SA-PVA-AC治疗有效地重新调节了血清AST和ALT的活性，表现出对肝功能的改善作用。结论：研究结果表明，SA-PVA 水凝胶中嵌入的活性炭作为治疗 AOPP 的治疗剂具有巨大潜力，并为管理农药引起的毒性提供了一种新方法。