Cerium dioxide nanoparticles (CeO NPs) are semiconductor metal oxide-based nanoparticles that possess the availability of “oxidation switch” on their surface. In response to external conditions, CeO NPs change the properties of surface Ce atoms, transforming into a core-shell structure. This unique property has been used in biomedical research and, in recent years, in analytics. However, there are very few works devoted to the use of CeO NPs in luminescence analysis. In this review, we summarize and critically discuss the use of CeO NPs in various luminescent signal detection methods as a luminescent nanolabel, luminescent nanosensor, luminescence quencher and nanozyme. Examples of CeO NPs utilizing as a nanosensor that provides high specificity are presented. At the same time, when used as a nanozyme, CeO NPs is very effective because they allow reversible enzyme-catalyzed reactions at physiological pH without the use of hydrogen peroxide and the enzyme itself. Further analytical applications and limitations of CeO NPs, which possess a set of unique properties, are also discussed.

中文翻译：

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用于基于发光的分析系统的二氧化铈纳米粒子：具有挑战性的纳米传感器和有效的标记

二氧化铈纳米颗粒（CeO NP）是一种基于半导体金属氧化物的纳米颗粒，其表面具有“氧化开关”。为了响应外部条件，CeO NPs 改变表面 Ce 原子的性质，转变为核壳结构。这种独特的特性已用于生物医学研究，近年来还用于分析。然而，致力于在发光分析中使用 CeO 纳米粒子的工作却很少。在这篇综述中，我们总结并批判性地讨论了 CeO 纳米粒子作为发光纳米标记、发光纳米传感器、发光猝灭剂和纳米酶在各种发光信号检测方法中的应用。介绍了 CeO 纳米颗粒用作提供高特异性的纳米传感器的例子。同时，当用作纳米酶时，CeO NPs非常有效，因为它们允许在生理pH下发生可逆的酶催化反应，而无需使用过氧化氢和酶本身。还讨论了具有一系列独特性质的 CeO 纳米颗粒的进一步分析应用和局限性。