After the eradication of smallpox, there have been no specific public health measures for any (OPXVs). Therefore, it is necessary to countermeasure OPXV infections after Mpox (formerly monkeypox) occurrences, such as the latest global outbreak in 2022–2023. This study aimed to provide crucial insights for the development of effective public health policy making against mpox in populations residing in regions where the virus is not prevalent. This study used enzyme-linked immunosorbent assays (ELISA) to examine smallpox and mpox antibodies in Koreans with three different age groups. We analyzed 56 sera obtained from a tertiary care hospital in South Korea between September 2022 and April 2023. Plasma levels of antibodies against the viral proteins of smallpox (variola cytokine response-modifying protein B) and MPXV (A29) were measured using enzyme-linked immunosorbent assays. Plasma samples from participants in their early 40 s and older exhibited higher reactivity to viral antigens than those from younger participants. Furthermore, there was a strong positive correlation in antibody positivity for the two different viruses across the sera. The presence of low antibody levels in participants ˂40 years may hinder their ability to defend against OPXV. Therefore, it is imperative to implement effective public health measures to mitigate the transmission of OPXV within the community. These findings serve as fundamental information for devising strategies to combat mpox efficiently, particularly in regions where the virus is not prevalent.

中文翻译：

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对正痘病毒的年龄相关抗体反应及其对公共卫生措施的影响：韩国研究的见解

消灭天花后，还没有针对任何天花（OPXV）的具体公共卫生措施。因此，有必要在 Mpox（以前称为猴痘）发生后应对 OPXV 感染，例如 2022-2023 年最新的全球疫情。这项研究旨在为针对居住在病毒不流行地区的人群制定有效的公共卫生政策提供重要见解。这项研究使用酶联免疫吸附测定（ELISA）来检测三个不同年龄组的韩国人的天花和mpox抗体。我们分析了 2022 年 9 月至 2023 年 4 月从韩国一家三级医院获得的 56 份血清。使用酶联法测量了天花病毒蛋白（天花细胞因子反应修饰蛋白 B）和 MPXV (A29) 的血浆抗体水平。免疫吸附测定。 40 岁出头及以上参与者的血浆样本比年轻参与者的血浆样本对病毒抗原表现出更高的反应性。此外，血清中两种不同病毒的抗体阳性率存在很强的正相关性。 40 岁以上参与者的抗体水平较低可能会阻碍他们防御 OPXV 的能力。因此，必须采取有效的公共卫生措施来减少 OPXV 在社区内的传播。这些发现为制定有效对抗MPOX的策略提供了基础信息，特别是在病毒不流行的地区。