There has been increased awareness of the linkage between environmental exposures and cardiovascular health and disease. Atrial fibrillation is the most common sustained cardiac arrhythmia, affecting millions of people worldwide and contributing to substantial morbidity and mortality. Although numerous studies have explored the role of genetic and lifestyle factors in the development and progression of atrial fibrillation, the potential impact of environmental determinants on this prevalent condition has received comparatively less attention. This review aims to provide a comprehensive overview of the current evidence on environmental determinants of atrial fibrillation, encompassing factors such as air pollution, temperature, humidity, and other meteorologic conditions, noise pollution, greenspace, and the social environment. We discuss the existing evidence from epidemiological and mechanistic studies, critically evaluating the strengths and limitations of these investigations and the potential underlying biological mechanisms through which environmental exposures may affect atrial fibrillation risk. Furthermore, we address the potential implications of these findings for public health and clinical practice and identify knowledge gaps and future research directions in this emerging field.

中文翻译：

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环境暴露与心房颤动：新证据和未来方向

人们越来越认识到环境暴露与心血管健康和疾病之间的联系。心房颤动是最常见的持续性心律失常，影响着全世界数百万人，导致很高的发病率和死亡率。尽管大量研究探讨了遗传和生活方式因素在心房颤动发生和进展中的作用，但环境决定因素对这种普遍病症的潜在影响相对较少受到关注。本综述旨在全面概述有关房颤环境决定因素的现有证据，包括空气污染、温度、湿度和其他气象条件、噪音污染、绿地和社会环境等因素。我们讨论流行病学和机制研究的现有证据，批判性地评估这些研究的优点和局限性，以及环境暴露可能影响心房颤动风险的潜在潜在生物学机制。此外，我们还探讨了这些发现对公共卫生和临床实践的潜在影响，并确定了这一新兴领域的知识差距和未来研究方向。