Background This retrospective study investigated the efficacy of endovascular treatment with multilayer flow modulators (MFMs) for treating aortic aneurysms in high-risk patients unsuitable for conventional treatments. Patients and methods Conducted from 2011 to 2019 at a single center, this retrospective observational study included 17 patients who underwent endovascular treatment with MFMs. These patients were selected based on their unsuitability for traditional surgical or endovascular procedures. The study involved meticulous pre-procedural planning, precise implantation of MFMs, and follow-up using CT angiography. The primary focus was on volumetric and flow volume changes in aneurysms, along with traditional diameter measurements. Moreover, the technical success and post-procedural complications were also registered. Results The technical success rate was 100%, and 30-day procedural complication rate was 17.6%. Post-treatment assessments revealed that 11 out of 17 patients showed a decrease in flow volume within the aneurysm sac, indicative of a favorable hemodynamic response. The median decrease in flow volume was 12 ml, with a median relative decrease of 8%. However, there was no consistent reduction in aneurysm size; most aneurysms demonstrated a median increase in volume for 46 ml and median increase in diameter for 18 mm. Conclusions While MFMs offer a potential alternative for high-risk aortic aneurysm patients, their effectiveness in preventing aneurysm expansion is limited. The results suggest that MFMs can provide a stable hemodynamic environment but do not reliably reduce aneurysm size. This underscores the need for ongoing vigilance and long-term monitoring in patients treated with this technology.

中文翻译：

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多层流量调节器治疗主动脉瘤的长期结果

背景 这项回顾性研究调查了多层血流调节器 (MFM) 血管内治疗对不适合常规治疗的高危患者主动脉瘤的疗效。患者和方法 这项回顾性观察研究于 2011 年至 2019 年在单一中心进行，纳入了 17 名接受 MFM 血管内治疗的患者。这些患者的选择是基于他们不适合传统外科手术或血管内手术。该研究涉及细致的术前计划、精确的 MFM 植入以及使用 CT 血管造影进行随访。主要重点是动脉瘤的体积和流量变化以及传统的直径测量。此外，还记录了技术上的成功和术后并发症。结果技术成功率为100%，30天手术并发症率为17.6%。治疗后评估显示，17 名患者中有 11 名显示动脉瘤囊内血流量减少，表明血流动力学反应良好。流量平均减少 12 毫升，平均相对减少 8%。然而，动脉瘤尺寸并没有持续减小；大多数动脉瘤的体积中位数增加了 46 毫升，直径中位数增加了 18 毫米。结论 虽然 MFM 为高危主动脉瘤患者提供了一种潜在的替代方案，但其预防动脉瘤扩张的效果有限。结果表明，MFM 可以提供稳定的血流动力学环境，但不能可靠地减小动脉瘤尺寸。这强调了对接受该技术治疗的患者持续保持警惕和长期监测的必要性。